Prostate epithelial cell differentiation and its relevance to the understanding of prostate cancer therapies

Clinical Science
Ronan M LongR William G Watson

Abstract

Prostate cancer is the most common malignancy in males in the western world. However, little is known about its origin and development. This review highlights the biology of the normal prostate gland and the differentiation of basal epithelial cells to a secretory phenotype. Alterations in this differentiation process leading to cancer and androgen-independent disease are discussed, as well as a full characterization of prostate epithelial cells. A full understanding of the origin and characteristics of prostate cancer epithelial cells will be important if we are to develop therapeutic strategies to combat the heterogeneous nature of this disease.

References

Apr 1, 1992·Surgical Oncology·G K IbrahimC N Robertson
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·H OkadaS Morii
Jan 1, 1992·Advances in Cancer Research·R Derynck
Jun 1, 1992·Seminars in Cell Biology·R Kemler
Aug 1, 1991·The Journal of Clinical Endocrinology and Metabolism·P CohenR G Rosenfeld
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D M HockenberyS J Korsmeyer
Jan 1, 1991·Trends in Biochemical Sciences·W B HuttnerP Rosa
Dec 1, 1986·Pathology, Research and Practice·N WernertG Dhom
Jun 1, 1987·Pathology, Research and Practice·P A AbrahamssonL Grimelius
Aug 1, 1988·The American Journal of Surgical Pathology·J E McNeal
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M KanW L McKeehan
Jan 1, 1989·The Prostate. Supplement·J T Isaacs, D S Coffey
Jan 1, 1985·Annual Review of Physiology·E R FroeschJ Zapf
Jan 1, 1988·Journal of Cell Science. Supplement·C S Potten, R J Morris
Feb 1, 1987·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·W L McKeehanD Fast
Jan 1, 1980·Annual Review of Biochemistry·P Bornstein, H Sage
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J R HassellG R Martin
Apr 14, 1995·Science·E A Clark, J S Brugge
Jan 1, 1995·Urological Research·M A NoordzijF H Schröder
Nov 1, 1993·Histochemistry·J L KrijnenT H van der Kwast
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·H Bonkhoff, K Remberger
Jan 1, 1996·The Prostate. Supplement·P A Abrahamsson

❮ Previous
Next ❯

Citations

Aug 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Vincent RouetVincent Goffin
Apr 25, 2009·The Journal of Biological Chemistry·Eva M NeuhausHanns Hatt
Jun 11, 2009·Physiology·Stephanie Z Young, Angélique Bordey
Nov 26, 2010·Cancer Research·Carolyn V UstachHyeong-Reh Choi Kim
May 3, 2008·Endocrinology·Jung Hoon LeeWen Xie
Jul 12, 2013·PloS One·Nadia B HassounahKimberly M McDermott
Jan 7, 2014·PloS One·LaTanya V WilliamsOlga V Volpert
Jan 16, 2014·International Journal of Oncology·Cristian E PobleteHector R Contreras
Aug 30, 2008·Wiener klinische Wochenschrift·Natalie SampsonPeter Berger
Mar 5, 2015·Journal of Cancer Research and Clinical Oncology·Gang DengZhijian Yu
Nov 26, 2010·Steroids·Dawn R CochraneJennifer K Richer
Oct 28, 2008·Seminars in Immunology·Michelle A NellerChristopher W Schmidt
Oct 24, 2007·American Journal of Clinical Pathology·Fernando Tadeu Andrade-Rocha
Jul 22, 2008·Experimental Gerontology·Christoph ZenzmaierPeter Berger
Mar 8, 2008·The Prostate·Taija M Kiviharju-Af Hällström, Marikki Laiho
Feb 6, 2008·Differentiation; Research in Biological Diversity·Hongjuan ZhaoDonna M Peehl
Dec 15, 2010·Integrative Cancer Therapies·Nesly DotanJamal Mahajna
Dec 18, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marjorie M WalkerPeter Clark
Jan 4, 2007·The Journal of Pathology·N SampsonP Berger
Apr 17, 2008·Cell Research·Kathleen Kelly, Juan Juan Yin
Dec 20, 2005·BJU International·Jack A Schalken
Jun 26, 2009·American Journal of Community Psychology·Jianhong LiuYue Zhuo
May 1, 2008·The AAPS Journal·Robert A Lionberger
Feb 1, 2017·The Journal of Pathology. Clinical Research·Boris DasenMaria Philippova
Jul 2, 2017·Journal of Cancer Research and Clinical Oncology·Claudia KesslerStefan Barth
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shu FengAlexander I Agoulnik
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ana L TeixeiraRui Medeiros
Apr 13, 2021·Precision Clinical Medicine·William Butler, Jiaoti Huang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Genes & Development
C Abate-Shen, M M Shen
Radiologic Clinics of North America
S W Hayward, G R Cunha
The Journal of Clinical Endocrinology and Metabolism
Ivan V LitvinovJohn T Isaacs
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Norman J Maitland, Anne T Collins
© 2021 Meta ULC. All rights reserved