Prostate field cancerization: deregulated expression of macrophage inhibitory cytokine 1 (MIC-1) and platelet derived growth factor A (PDGF-A) in tumor adjacent tissue

PloS One
Anna C JonesMarco Bisoffi

Abstract

Prostate field cancerization denotes molecular alterations in histologically normal tissues adjacent to tumors. Such alterations include deregulated protein expression, as we have previously shown for the key transcription factor early growth response 1 (EGR-1) and the lipogenic enzyme fatty acid synthase (FAS). Here we add the two secreted factors macrophage inhibitory cytokine 1 (MIC-1) and platelet derived growth factor A (PDGF-A) to the growing list of protein markers of prostate field cancerization. Expression of MIC-1 and PDGF-A was measured quantitatively by immunofluorescence and comprehensively analyzed using two methods of signal capture and several groupings of data generated in human cancerous (n = 25), histologically normal adjacent (n = 22), and disease-free (n = 6) prostate tissues. A total of 208 digitized images were analyzed. MIC-1 and PDGF-A expression in tumor tissues were elevated 7.1x to 23.4x and 1.7x to 3.7x compared to disease-free tissues, respectively (p<0.0001 to p = 0.08 and p<0.01 to p = 0.23, respectively). In support of field cancerization, MIC-1 and PDGF-A expression in adjacent tissues were elevated 7.4x to 38.4x and 1.4x to 2.7x, respectively (p<0.0001 to p<0.05 and p<0.05 to p = 0.51, respect...Continue Reading

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Citations

Sep 17, 2016·International Journal of Oncology·Kristin N GabrielMarco Bisoffi
Jun 8, 2017·Experimental and Therapeutic Medicine·Shu LuPeiming Bai
Apr 25, 2019·Scientific Data·Maria SuntsovaAnton Buzdin
Jul 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jun Seop LeeJyongsik Jang
Apr 1, 2019·Molecular Cancer·Zehuan LiaoNguan Soon Tan
Feb 13, 2019·Molecular Cancer Research : MCR·Elizabeth C RandallNathalie Y R Agar
May 1, 2021·Cancers·Mathushan SubasriDean H Betts
May 13, 2021·Immunity·Matthew B BuechlerShannon J Turley

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