Prostate histotripsy in an anticoagulated model.

Urology
Jeffery C WheatWilliam W Roberts

Abstract

To further explore the phenomenon of minimal bleeding after histotripsy by performing extensive prostate histotripsy treatments in anticoagulated canines. Histotripsy is a noninvasive ultrasound technology which induces microbubble formation (cavitation) within tissues producing mechanical tissue fractionation. During initial in vivo feasibility canine studies of prostate ablation, minimal hematuria was observed. Histotripsy was performed on 9 canine subjects pretreated with 6 mg of oral warfarin for 3-5 days using an extracorporeal 750 kHz therapeutic ultrasound transducer delivering acoustic pulses to the prostatic urethra and periurethral parenchyma. After 7-28 days, the subjects were euthanized, transrectal prostate ultrasound was performed, and the prostate was harvested. Serum hemoglobin and International Normalization Ratio were measured immediately before histotripsy treatment and at euthanasia. Mean treatment International Normalization Ratio was 4.6 (median, 2.4; range, 1.2-11.3). There was no clinically significant change in hemoglobin concentration at euthanasia compared with baseline. At harvest, histologic sections of the prostate revealed a large cavity corresponding to the planned treatment volume incorporating ...Continue Reading

References

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Jul 25, 2009·Urology·Timothy L HallWilliam W Roberts

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Citations

Nov 16, 2013·Current Opinion in Urology·William W Roberts
Jun 26, 2010·Journal of Endourology·Nicholas R StynWilliam W Roberts
Sep 25, 2012·The Journal of Urology·George R SchadeWilliam W Roberts
Jul 31, 2012·Urology·George R SchadeWilliam W Roberts
Feb 22, 2011·The Journal of Urology·Christopher R HempelWilliam W Roberts
Nov 2, 2013·BJU International·George R SchadeWilliam W Roberts
Jun 25, 2014·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Tzu-Yin WangCharles A Cain
Feb 25, 2015·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Vera A KhokhlovaCharles A Cain
Mar 31, 2015·Ultrasound in Medicine & Biology·Martijn HoogenboomGosse J Adema
Sep 10, 2013·The Journal of Urology·William W RobertsJames A Bertolina
Jan 18, 2019·Journal of Veterinary Emergency and Critical Care·Marie-Claude BlaisClaire R Sharp
Nov 30, 2018·Journal of Neurosurgery·Jonathan R SukovichZhen Xu
May 22, 2019·Physical Review. E·Chad T WilsonJonathan R Sukovich
Apr 9, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Zhen XuFred T Lee
May 27, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·John F SwietlikTimothy J Ziemlewicz
Jun 22, 2017·Ultrasonics Sonochemistry·Martijn HoogenboomGosse J Adema

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