Abstract
To further explore the phenomenon of minimal bleeding after histotripsy by performing extensive prostate histotripsy treatments in anticoagulated canines. Histotripsy is a noninvasive ultrasound technology which induces microbubble formation (cavitation) within tissues producing mechanical tissue fractionation. During initial in vivo feasibility canine studies of prostate ablation, minimal hematuria was observed. Histotripsy was performed on 9 canine subjects pretreated with 6 mg of oral warfarin for 3-5 days using an extracorporeal 750 kHz therapeutic ultrasound transducer delivering acoustic pulses to the prostatic urethra and periurethral parenchyma. After 7-28 days, the subjects were euthanized, transrectal prostate ultrasound was performed, and the prostate was harvested. Serum hemoglobin and International Normalization Ratio were measured immediately before histotripsy treatment and at euthanasia. Mean treatment International Normalization Ratio was 4.6 (median, 2.4; range, 1.2-11.3). There was no clinically significant change in hemoglobin concentration at euthanasia compared with baseline. At harvest, histologic sections of the prostate revealed a large cavity corresponding to the planned treatment volume incorporating ...Continue Reading
References
Dec 1, 1989·British Journal of Urology·N J ParrA D Desmond
May 23, 1998·British Journal of Urology·A Chakravarti, S MacDermott
Jan 12, 2000·American Journal of Veterinary Research·E Monnet, M R Morgan
Dec 24, 2002·Prostate Cancer and Prostatic Diseases·W MahapokaiJ A Schalken
Nov 12, 2003·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Binh C TranCharles A Cain
Feb 12, 2005·The Journal of the Acoustical Society of America·Zhen XuCharles A Cain
Jan 13, 2006·The Journal of Urology·William W RobertsCharles A Cain
Feb 14, 2006·European Urology·Jens RassweilerRainer Hofmann
Mar 7, 2006·The Journal of Urology·Ehab ElzayatMostafa Elhilali
Sep 2, 2006·European Urology·Robin RuszatAlexander Bachmann
Jun 19, 2007·The Journal of Urology·Kathleen KieranWilliam W Roberts
Aug 31, 2007·The British Journal of Surgery·A TanY Cao
Nov 21, 2007·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Zhen XuCharles A Cain
Mar 18, 2008·Urology·Alison M LakeWilliam W Roberts
May 20, 2008·European Urology·Robin RuszatAlexander Bachmann
Oct 11, 2008·BMJ : British Medical Journal·Tania LourencoUNKNOWN Benign Prostatic Enlargement team
Jul 25, 2009·Urology·Timothy L HallWilliam W Roberts
Citations
Nov 5, 2011·Journal of Endourology·George R SchadeWilliam W Roberts
Nov 16, 2013·Current Opinion in Urology·William W Roberts
Jun 26, 2010·Journal of Endourology·Nicholas R StynWilliam W Roberts
Sep 25, 2012·The Journal of Urology·George R SchadeWilliam W Roberts
Jul 31, 2012·Urology·George R SchadeWilliam W Roberts
Feb 22, 2011·The Journal of Urology·Christopher R HempelWilliam W Roberts
Nov 2, 2013·BJU International·George R SchadeWilliam W Roberts
Jun 25, 2014·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Tzu-Yin WangCharles A Cain
Feb 25, 2015·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Vera A KhokhlovaCharles A Cain
Mar 31, 2015·Ultrasound in Medicine & Biology·Martijn HoogenboomGosse J Adema
Sep 10, 2013·The Journal of Urology·William W RobertsJames A Bertolina
Sep 20, 2016·PloS One·Jinlong ZhangZheng Liu
Apr 2, 2017·Tissue Engineering. Part a·Chen ChenYihua Zhang
Jan 18, 2019·Journal of Veterinary Emergency and Critical Care·Marie-Claude BlaisClaire R Sharp
Sep 13, 2011·Pediatric Cardiology·Gabe E OwensZhen Xu
Nov 30, 2018·Journal of Neurosurgery·Jonathan R SukovichZhen Xu
May 22, 2019·Physical Review. E·Chad T WilsonJonathan R Sukovich
Apr 9, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Zhen XuFred T Lee
May 27, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·John F SwietlikTimothy J Ziemlewicz
Jun 22, 2017·Ultrasonics Sonochemistry·Martijn HoogenboomGosse J Adema