Prostate irradiation with focal dose escalation to the intraprostatic dominant nodule: a systematic review

Prostate International
Thomas Feutren, F G Herrera

Abstract

Radiation therapy (RT) is a curative treatment option for localized prostate cancer. Prostate irradiation with focal dose escalation to the intraprostatic dominant nodule (IDN) is an emerging treatment option that involves the prophylactic irradiation of the whole prostate while increasing RT doses to the visible prostatic tumor. Because of the lack of large multicentre trials, a systematic review was performed in an attempt to get an overview on the feasibility and efficacy of focal dose escalation to the IDN. A bibliographic search for articles in English, which were listed in MEDLINE from 2000 to 2016 to identify publications on RT with focal directed boost to the IDN, was performed. The review was completed following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Twenty-two articles describing 1,378 patients treated with RT using focal boost were identified and fulfilled the selection criteria. Intensity-modulated radiation therapy (IMRT) was used in 720 patients (52.3%), volumetric modulated arc therapy was used in 45 patients (3.3%), stereotactic body radiation therapy (SBRT) in 113 patients (8.2%), and low-dose rate and high-dose rate brachytherapy (BT) were used in 305 patients (22.1%...Continue Reading

Citations

Oct 28, 2019·Journal of Medical Imaging and Radiation Oncology·Stephen ChinAnanya Choudhury
May 23, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Kazuo HatanoKoichi Konoeda
Mar 1, 2020·Nature Reviews. Clinical Oncology·Derek J Lomas, Hashim U Ahmed
Nov 5, 2020·Clinical and Translational Radiation Oncology·Luke NichollsNicholas van As
Jan 21, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Linda G W KerkmeijerUulke A van der Heide
Sep 10, 2021·Urologia·Francesco CelliniVincenzo Valentini

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Methods Mentioned

BETA
imaging techniques
biopsy
biopsies

Clinical Trials Mentioned

NCT02254746

Software Mentioned

HYPORT
RStudio

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