Prostate Microstructure in Prostate Cancer Using 3-T MRI with Diffusion-Relaxation Correlation Spectrum Imaging: Validation with Whole-Mount Digital Histopathology

Radiology
Zhaohuan ZhangDieter R Enzmann

Abstract

Background Microstructural MRI has the potential to improve diagnosis and characterization of prostate cancer (PCa), but validation with histopathology is lacking. Purpose To validate ex vivo diffusion-relaxation correlation spectrum imaging (DR-CSI) in the characterization of microstructural tissue compartments in prostate specimens from men with PCa by using registered whole-mount digital histopathology (WMHP) as the reference standard. Materials and Methods Men with PCa who underwent 3-T MRI and robotic-assisted radical prostatectomy between June 2018 and January 2019 were prospectively studied. After prostatectomy, the fresh whole prostate specimens were imaged in patient-specific three-dimensionally printed molds by using 3-T MRI with DR-CSI and were then sliced to create coregistered WMHP slides. The DR-CSI spectral signal component fractions (fA, fB, fC) were compared with epithelial, stromal, and luminal area fractions (fepithelium, fstroma, flumen) quantified in PCa and benign tissue regions. A linear mixed-effects model assessed the correlations between (fA, fB, fC) and (fepithelium, fstroma, flumen), and the strength of correlations was evaluated by using Spearman correlation coefficients. Differences between PCa and...Continue Reading

References

Jun 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J DelannoyD Le Bihan
Jul 19, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Roger M BourneWilliam S Price
Feb 5, 2014·Cancer Research·Eletheria PanagiotakiDaniel C Alexander
Feb 28, 2015·Magnetic Resonance Imaging·Carlos F UribePiotr Kozlowski
Nov 21, 2015·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Yu Xuan KitzingAytekin Oto
May 31, 2016·Diagnostics·Roger Bourne, Eleftheria Panagiotaki
Oct 12, 2016·AJR. American Journal of Roentgenology·Tristan Barrett, Masoom A Haider
Jan 29, 2017·Journal of Magnetic Resonance Imaging : JMRI·Shirin SabouriPiotr Kozlowski
Feb 12, 2017·Investigative Radiology·Gregory LemberskiyEls Fieremans
Mar 21, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Daeun KimJustin P Haldar
Sep 26, 2017·NeuroImage·Dan Benjamini, Peter J Basser
Dec 5, 2018·European Urology·David C JohnsonRobert E Reiter
Dec 20, 2018·Cell Reports·Gervaise H HenryDouglas W Strand

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Citations

Jun 11, 2020·Radiology·Susanna I Lee, Stefanie J Hectors
Jun 1, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Markus NilssonFredrik Jäderling
Aug 20, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Paddy J SlatorJana Hutter

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