Prostate positioning errors associated with two automatic registration based image guidance strategies.

Journal of Applied Clinical Medical Physics
D RyanB Gino Fallone

Abstract

Daily image guidance for helical tomotherapy prostate patients is based on the registration of pre-treatment megavoltage CT (MVCT) images and the original planning CT. The goal of registration, whether manual or automatic, is the overlap of the prostate; otherwise prostate misplacement may compromise the efficacy of treatment or lead to increased toxicity. A previous study demonstrated that without the aid of implanted fiducials, manual registration results in inaccurate prostate positioning. The objective of this work is to quantify prostate misplacement that results from automatic bone matching (BM) and image matching (IM) registration algorithms. 204 MVCT images from 8 high risk tomotherapy prostate patients were incorporated into this retrospective study. BM and IM registration algorithms--based on maximization of mutual information of bony anatomy only and the entire image, respectively--were used to independently register MVCT images to their respective planning images. A correlation coefficient based algorithm that uses known planning CT contour information was used for automatic prostate localization in each MVCT image. Daily prostate misplacement was determined by repositioning as calculated from the BM and the IM algo...Continue Reading

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Citations

Oct 10, 2012·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Erik DzintarsSotirios Stathakis
Feb 4, 2012·International Journal of Radiation Oncology, Biology, Physics·Vedang MurthyShyamkishore Shrivastava

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