Prostate rebiopsy is a poor surrogate of treatment efficacy in localized prostate cancer

The Journal of Urology
D SvetecI M Thompson

Abstract

Many investigators use prostate rebiopsy as an indicator of treatment efficacy and tumor response of localized prostate cancer for therapies in which the gland remains in situ. Because of the inherent sampling error of needle directed biopsies, however, some men will have a false-negative rebiopsy even if they have had no therapy or if the therapeutic intervention was unsuccessful in eradicating the malignancy. We evaluate the risk of a false-negative biopsy and the clinical factors that influence this risk. A total of 90 patients undergoing radical prostatectomy for clinically localized disease underwent sextant biopsy of the prostate immediately after removal of the gland. Data collected included prostate specific antigen (PSA), hormonal status, age and biopsy core status. Of the total study population 67.8% received neoadjuvant hormonal therapy. While all patients had pathologically confirmed adenocarcinoma within the prostatectomy specimen, 45.6% demonstrated a false-negative rebiopsy. Within a combined predictive model, PSA and hormonal status demonstrated a statistically significant effect on the false-negative rebiopsy rate. Predictive power of this combined model was high across the spectrum of risk for a false-negative...Continue Reading

Citations

Sep 10, 2003·Current Problems in Cancer·Judd W Moul
Sep 7, 2000·International Journal of Radiation Oncology, Biology, Physics·J CrookM Abdolell
May 10, 2003·International Journal of Radiation Oncology, Biology, Physics·Jonathan I IzawaLouis L Pisters
Mar 22, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Svend O FreytagJae Ho Kim
Apr 5, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Svend O FreytagJae Ho Kim
Jun 11, 2009·Topics in Magnetic Resonance Imaging : TMRI·Katarzyna J Macura
May 22, 2009·AJR. American Journal of Roentgenology·Baris TurkbeyPeter L Choyke
May 18, 2005·Asian Journal of Andrology·Mohammed Ahmed Al-GhazoIsmail Ibrahim Matalka
May 17, 2011·Radiographics : a Review Publication of the Radiological Society of North America, Inc·David BonekampKatarzyna J Macura
Oct 24, 2012·The Journal of Urology·Misop HanDan Stoianovici
Nov 23, 2011·Ultrasound in Medicine & Biology·Liang ZhaiKathryn R Nightingale
Nov 24, 2011·Prostate Cancer·J L Dominguez-EscrigD Greene
Mar 19, 2004·International Journal of Urology : Official Journal of the Japanese Urological Association·John Shyi Peng YuenChristopher Wai Sam Cheng
Feb 18, 2005·European Urology·Hasan Serkan DoganHaluk Ozen
Jul 5, 2005·Urology·Gregory S MerrickWayne M Butler
Jan 13, 2015·La Radiologia medica·Anna Micaela CiarrapicoGiovanni Simonetti
May 8, 2000·The Journal of Urology·J W Moul
Apr 8, 2006·The Journal of Urology·Ian M Thompson, M Scott Lucia
May 15, 2007·Urologia Internationalis·Konstantinos StamatiouFrangiskos Sofras
Mar 22, 2000·Current Opinion in Urology·R G Aarnink, H Wijkstra
Feb 22, 2017·Current Oncology Reports·Jamil S SyedPreston C Sprenkle
May 9, 2003·The Urologic Clinics of North America·Eric A Klein, Patrick A Kupelian

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