Prostate screening in patients with 46,XY disorders of sex development--is it necessary?

The Journal of Urology
Amirali Hassanzadeh SalmasiYegappan Lakshmanan

Abstract

We used current methods of screening for prostate cancer, digital rectal examination and serum prostate specific antigen as an initial assessment of risk in a young group of adult 46,XY patients affected by disorders of sex development. Adult intersex patients older than 21 years, under long-term followup at the Pediatric Endocrinology Clinic of the Johns Hopkins Hospital, with a diagnosis of male psuedohermaphroditism and raised as male or female were included in analysis. After written consent all participants underwent digital rectal examination and blood sampling for prostate specific antigen and testosterone measurements. Prostate specific antigen values were available for analysis in 26 patients. Diagnoses included micropenis (8), complete androgen insensitivity syndrome (3), partial androgen insensitivity syndrome (9) and mixed gonadal dysgenesis (6). Of the 26 patients 9 had been raised as female (complete androgen insensitivity syndrome in 3, partial androgen insensitivity syndrome in 3, micropenis in 2 and mixed gonadal dysgenesis in 1). Mean patient age was 38 years (range 24 to 57). Serum prostate specific antigen was less than 0.1 ng/ml in 18 patients including the 9 reared as female. The remaining 8 patients had a...Continue Reading

References

Jul 1, 1994·The Journal of Urology·I A Aaronson
Nov 5, 1997·Human Molecular Genetics·S E AndrewM R Hayden
Feb 9, 1999·Vitamins and Hormones·A K RoyB Chatterjee
Jul 29, 1999·Human Mutation·B GottliebM Trifiro
Jan 5, 2000·Seminars in Surgical Oncology·L J Denis, K Griffiths
Aug 18, 2000·The Journal of Clinical Endocrinology and Metabolism·A B WisniewskiJ Money
Jun 1, 2001·The Journal of Steroid Biochemistry and Molecular Biology·D M AvilaM J McPhaul
Jun 23, 2001·Molecular and Cellular Endocrinology·A O Brinkmann
May 18, 2004·Human Mutation·Bruce GottliebMark Trifiro
Jan 31, 2007·The Prostate·Xu-Bao ShiRalph W DeVere White
Mar 30, 2007·CA: a Cancer Journal for Clinicians·Robert A SmithHarmon J Eyre

❮ Previous
Next ❯

Citations

Jun 23, 2009·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·C BouvattierP Chatelain
Jan 2, 2013·Journal of Pediatric Urology·Eric Z MassanyiJohn P Gearhart
Nov 15, 2011·Journal of Pediatric Urology·Blake W PalmerBradley P Kropp
May 26, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Berenice B MendoncaJean D Wilson
Jun 4, 2010·Arquivos brasileiros de endocrinologia e metabologia·Juliana Gabriel Ribeiro de AndradeAndréa Trevas Maciel-Guerra
Oct 1, 2010·The Journal of Clinical Endocrinology and Metabolism·Glenn R Cunningham, Shivani M Toma
Nov 1, 2009·Expert Review of Endocrinology & Metabolism·Alaa CheikhelardClaire Nihoul-Fekete

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved