Prostate small cell carcinoma and skin metastases: a rare entity

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
Yesim YildirimBulent Celasun

Abstract

To report a rare case of small cell carcinoma of the prostate with unusual skin metastasis. A 60-year-old was evaluated for difficulty in urinating. Abdominal computed tomography scans revealed a prostatic mass invading the surrounding tissues and multiple perirectal, periprostatic, para-aortic and pericaval lymph nodes. Needle biopsy specimens showed both small cell carcinoma and adenocarcinoma. He was treated with combination chemotherapy: cisplatin and etoposide and bilateral orchiectomy. After six cycles of the chemotherapy, disease progressed and the patient did not respond to salvage therapy; hence, palliative care was instituted. During the follow-up, papillary lesions were observed in the scrotal skin; biopsy showed metastatic small cell carcinoma. Small cell carcinoma of the prostate is an aggressive disease with a highly metastatic potential; but skin metastases are very uncommon. It has poor prognosis despite therapy. Management resembles that of small cell carcinoma of the lung.

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Citations

May 24, 2012·The American Journal of Dermatopathology·Inmaculada AlcarazLuis Requena
Aug 21, 2012·Diagnostic Pathology·Eugen Bogdan PetcuKlara Brinzaniuc
Jun 3, 2014·Journal of Medical Case Reports·Kursat CecenRamazan Kocaaslan
Dec 17, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·T Lebret, A Méjean
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Apr 11, 2015·Case Reports in Urology·Parth PatelSameer Siddiqui
Apr 24, 2018·Case Reports in Urology·Israel Antonio Esquivel-PintoJuan Pablo Castanedo-Cázares
Sep 24, 2020·Case Reports in Urology·Idriss ZianiYassine Nouini

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