Prostate-specific antigen and prognosis in patients with metastatic prostate cancer--a multivariable analysis of prostate cancer mortality

British Journal of Urology
J M ReynardD Gillatt

Abstract

To analyse the prognostic significance of pre- and post-treatment serum prostate-specific antigen (PSA) levels, together with a variety of other factors, in a multivariable analysis of survival in men with stage D2 prostate cancer. Cox's proportional hazards model was used to compare survival in 134 men with stage D2 metastatic prostate cancer followed prospectively over a 4 year period, using both univariable and multivariable models. The influence of the following factors on survival was analysed: pre- and post-treatment PSA (both absolute and percentage values), age, treatment, testosterone, pre- and post-treatment alkaline phosphatase (absolute and percentage values), acid phosphatase, haemoglobin, symptom score and performance status and extent of disease on bone scan. Pre-treatment PSA levels did not significantly influence survival. Similarly, a low absolute post-treatment PSA level at 3 months after the start of treatment conferred no survival advantage relative to patients with a high PSA level at this time. A post-treatment percentage PSA of < 10% at 2, 3 and 6 months after commencement of treatment was associated with prolonged survival. Low pre-treatment alkaline phosphatase (less than the upper limit of normal) and...Continue Reading

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Citations

Jul 24, 2003·European Urology·Laurence ColletteUNKNOWN EORTC Genito-Urinary Group
Nov 9, 2000·BJU International·W D DunsmuirR S Kirby
Nov 13, 2007·The Journal of Urology·David RobinsonUNKNOWN Scandinavian Prostate Cancer Group (SPCG)-5
Jun 3, 2015·BJU International·Rami KlaffUNKNOWN Scandinavian Prostate Cancer Group (SPCG) Study No. 5
Aug 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maha HussainUNKNOWN Southwest Oncology Group Trial 9346 (INT-0162)
May 2, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Norihiko TsuchiyaTomonori Habuchi
Jun 9, 2006·Expert Review of Anticancer Therapy·Jyoti ShahPrasanna Sooriakumaran
Apr 22, 2009·Scandinavian Journal of Urology and Nephrology·Arto MikkolaUNKNOWN Finnprostate Group
Nov 27, 2019·International Journal of Clinical Oncology·Keiichiro MoriShahrokh F Shariat
Mar 10, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P SabbatiniH I Scher
Nov 7, 1998·Cancer Treatment Reviews·A J Dowling, I F Tannock

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