PMID: 11920529Mar 29, 2002Paper

Prostate specific antigen complexed to alpha-1-antichymotrypsin in patients with intermediate prostate specific antigen levels

Cancer
Takashi SaikaOkayama Urological Cancer Collaborating Group

Abstract

The authors attempted to evaluate prospectively the usefulness of serum prostate specific antigen (PSA) complexed to alpha-1-antichymotrypsin (PSA-ACT) in the early detection of prostate carcinoma and its ability to discriminate between prostate carcinoma and benign prostatic hyperplasia (BPH), especially among patients with intermediate PSA levels. Between December 1999 and August 2000, systematic sextant biopsies were performed on 281 prospective patients with prostate carcinoma who had serum PSA levels between 4.1 ng/mL and 20.0 ng/mL. The serum samples were assayed by using kits that were designed specifically for measuring serum PSA, PSA-ACT, and free PSA levels. The clinical values of PSA, PSA-ACT, the free PSA to total PSA ratio (F/T ratio), the free PSA to PSA-ACT ratio, PSA density (PSAD), and PSA-ACT density (ACTD) were compared by using receiver operating characteristic (ROC) curve analysis. Biopsy yielded no evidence of malignancy in 198 patients, and prostate carcinoma was confirmed in 83 patients. ROC analysis demonstrated that the area under the curve (AUC) for PSA-ACT was greater than that for total PSA and was equivalent to that for the F/T ratio in both groups of patients (PSA ranges of 4.1-20.0 ng/mL and 4.1-...Continue Reading

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Citations

Jul 29, 2008·Actas urologicas españolas·J M Alapont AlacreuJ F Jiménez Cruz
Dec 6, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Takashi KobayashiYoshihiro Ide
Jun 14, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Kikuo OkamuraTetsuro Nagasaka
Dec 15, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Takashi KobayashiYoshihiro Ide
Sep 22, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Yojiro NakanoTetsuro Nagasaka
Sep 22, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Takashi KobayashiToshiyuki Kamoto
Mar 11, 2004·BJU International·M H WinklerD A Gillatt
Jul 16, 2008·Journal of Clinical Laboratory Analysis·Yuhsaku KanohTohru Akahoshi

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