Prostate-specific antigen decline pattern in advanced prostate cancer receiving androgen deprivation therapy and relationship with prostate-specific antigen progression

The Aging Male : the Official Journal of the International Society for the Study of the Aging Male
Erdem AkbayCuma Aytekin

Abstract

The aim of this study is to evaluate prostate-specific antigen decline pattern including prostate-specific antigen kinetics following androgen deprivation therapy on prostate-specific antigen progression in the patients with advanced prostate cancer. Ninety-seven advanced prostate cancer patients receiving maximum androgen deprivation therapy were enrolled in case-control study. Baseline prostate-specific antigen, Gleason Score, bone metastase, nadir prostate-specific antigen, time to nadir prostate-specific antigen, declining slope to nadir prostate-specific antigen, estimated baseline prostate-specific antigen half-time, current prostate-specific antigen, post-nadir prostate-specific antigen time, estimated prostate-specific antigen, estimated decline of baseline prostate-specific antigen as quantitative, and ratio were recorded and calculated. The ratio of prostate-specific antigen progression was significantly lower at the patients who had slower declining slope to prostate-specific antigen, longer time to nadir prostate-specific antigen, and lower estimated decline ratio of baseline prostate-specific antigen (p: .016, p: .020, and p: .026, respectively). The shorter time to nadir prostate-specific antigen following androge...Continue Reading

References

Aug 17, 1989·The New England Journal of Medicine·E D CrawfordP J Goodman
Jan 9, 2004·International Journal of Cancer. Journal International Du Cancer·Juan MoroteJaume Reventos
Sep 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexandra J StewartAnthony V D'Amico
Aug 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maha HussainUNKNOWN Southwest Oncology Group Trial 9346 (INT-0162)
Mar 20, 2008·The Journal of Clinical Endocrinology and Metabolism·Sadeka ShahaniShehzad Basaria
May 28, 2011·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Shu-Pin HuangWen-Jeng Wu
Mar 10, 2015·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Hayato UrushimaKazuhisa Maeda
May 26, 2015·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Jeremy Yuen Chun TeohChi-Fai Ng
Aug 1, 2015·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·ZhiLong DongXiaoDong Xie
Sep 17, 2016·Turkish Journal of Urology·Paul F Schellhammer
Jan 10, 2017·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Jhen-Hao JhanChia-Chun Tsai
Mar 12, 2017·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Aksam YassinDany-Jan Yassin

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.