Prostate Specific Antigen Density as a Predictor of Clinically Significant Prostate Cancer When the Prostate Specific Antigen is in the Diagnostic Gray Zone: Defining the Optimum Cutoff Point Stratified by Race and Body Mass Index

The Journal of Urology
Alireza AminsharifiThomas J Polascik

Abstract

We assessed the predictive value of prostate specific antigen density to detect clinically significant prostate cancer, defined as prostate cancer grade group 2 or greater, in a series of men undergoing prostate biopsy with prostate specific antigen 4 to 10 ng/ml. We sought to define an optimum cutoff point for prostate specific antigen density and assess how race and body mass index affects prostate specific antigen density performance. We analyzed data on 2,162 men, of whom 56% were African American, with serum prostate specific antigen 4 to 10 ng/ml who underwent prostate biopsy. We compared the AUC between prostate specific antigen and prostate specific antigen density to predict clinically significant and any prostate cancer vs no cancer. We calculated the negative predictive value of prostate specific antigen density cutoff points ranging from 0.05 to 0.15 by every 0.01 step. We a priori defined the optimal cutoff point of prostate specific antigen density as a negative predictive value of 95% and tested whether the cutoff was sensitive to body mass index and race by comparing the negative predictive value across strata. Median prostate specific antigen was 5.6 ng/ml (IQR 4.8-7) and median prostate specific antigen densit...Continue Reading

References

May 5, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Koichi OkadaTsuneharu Miki
Jul 9, 2011·BJU International·Ryan P KoppJ Kellogg Parsons
Jan 27, 2016·BMJ : British Medical Journal·Andrew J VickersEwout W Steyerberg
Dec 21, 2017·Prostate Cancer and Prostatic Diseases·Tobias NordströmMartin Eklund

❮ Previous
Next ❯

Citations

May 15, 2020·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Sinan Avci, Volkan Caglayan
Sep 24, 2019·World Journal of Gastroenterology : WJG·Du CaiYan-Xin Luo
Nov 25, 2020·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Tânia GagoHorácio Guerreiro
Mar 7, 2020·Photodiagnosis and Photodynamic Therapy·K AkshayaR Murugesan
Jun 8, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Manuel M GarridoJoão T Guimarães
Aug 7, 2021·Journal of Personalized Medicine·James MeehanArran K Turnbull

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Disparities

Cancer disparities refers to differences in cancer outcomes (e.g., number of cancer cases, related health complications) across population groups.