Prostate specific antigen density as a prognostic factor for patients with prostate carcinoma treated with radiotherapy

Cancer
A PollackR J Babaian

Abstract

The pretreatment serum prostate specific antigen level (PSAL) is the most significant predictor of biochemical and local failure in patients treated with definitive radiotherapy. The role of prostate specific antigen (PSA) density (PSAD) relative to PSAL for such patients is controversial. In this article, we describe a comparative analysis of the prognostic value of PSAL and PSAD. The study was comprised of 365 patients who were treated with external beam radiotherapy for regionally localized (T1-T4, Nx, M0) adenocarcinoma of the prostate between 1987-1993 and in whom PSAL and pretreatment prostate volume by transrectal ultrasound were available. The mean and median doses were 66.8 Gy and 66 Gy. Median follow-up for those patients living was 27 months. The mean PSAL was 12.7 ng/mL with a median of 9.1 ng/mL. PSAD was calculated by dividing the PSAL by the pretreatment prostate transectal ultrasound volume (in cc). The mean PSAD was 0.44 and the median was 0.31. Biochemical failure was defined as two consecutive increases in follow-up PSAs, one increase by a factor of greater than 1.5 of an absolute increase of greater than 1 ng/mL. The distributions of PSAD and PSAL were similar and were positively skewed. When log-transformed...Continue Reading

References

Feb 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W R LeeM A Hunt
May 15, 1995·International Journal of Radiation Oncology, Biology, Physics·G K ZagarsA C von Eschenbach
Aug 30, 1995·International Journal of Radiation Oncology, Biology, Physics·G K ZagarsA C von Eschenbach
Sep 1, 1993·International Journal of Radiation Oncology, Biology, Physics·P G ZentnerP B Schiff
Nov 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T M PisanskyJ E Oesterling
Feb 1, 1996·International Journal of Radiation Oncology, Biology, Physics·A PollackI I Rosen

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Citations

Oct 27, 1998·International Journal of Radiation Oncology, Biology, Physics·J D SlaterJ M Slater
May 1, 1997·The Urologic Clinics of North America·M C Beduschi, J E Oesterling
Dec 10, 1997·International Journal of Radiation Oncology, Biology, Physics·A Pollack, G K Zagars

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