PMID: 7538598Jun 1, 1995Paper

Prostate specific antigen density is not an independent predictor of response for prostate cancer treated by conformal radiotherapy

The Journal of Urology
B W CornT E Schultheiss

Abstract

Although prostate specific antigen (PSA) density appears to be an important discriminator between benign and malignant prostatic disease, conflicting data exist concerning its prognostic value. The present study was undertaken to confirm whether PSA density represents a new prognostic indicator of disease-free survival for prostate cancer treated with conformal radio-therapy. Between April 1989 and December 1992, 186 patients with organ confined prostate cancer were treated with definitive irradiation according to previously published conformal guidelines. The PSA density was defined as the ratio of the pretreatment serum PSA (ng./ml.) to the prostate volume (ml.) as determined from treatment planning computerized tomography. The median PSA density was 0.15 with a range of 0.02 to 2.12. A statistically significant advantage in actuarial freedom from biochemical relapse was noted for patients with pretreatment PSA levels less than 15 ng./ml. when compared to those with higher pretreatment PSA levels (3-year freedom from biochemical relapse 85% versus 28%, p < 0.001). Also, patients with PSA density of 0.15 or less had statistically superior freedom from biochemical relapse compared to their counterparts with higher PSA density (...Continue Reading

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Citations

Oct 23, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C FiorinoR Calandrino
Jan 5, 2002·International Journal of Radiation Oncology, Biology, Physics·David J BrennerElwood P Armour
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May 1, 1997·The Urologic Clinics of North America·M C Beduschi, J E Oesterling

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