PMID: 8583584Mar 1, 1996Paper

Prostate specific antigen detected prostate cancer (clinical stage T1c): an interim analysis

The Journal of Urology
S E LernerH Zincke

Abstract

The majority of impalpable prostate cancers (state T1c) are biologically significant. We report the interim results in 257 patients with stage T1c prostate cancer treated with radical prostatectomy. Prostate specific antigen progression-free survival was assessed by the Kaplan-Meier method. Multivariate analyses were performed to determine which clinical and pathological variables independently correlated with progression. Comparisons among the various clinical substages (T1a to T2b/c) were calculated. Of the patients with stage T1c cancers 51% had stage pT2c or less and 91% had clinically significant tumors on the basis of pathological grade, deoxyribonucleic acid ploidy and tumor volume. High preoperative prostate specific antigen, poorly differentiated tumors and nondiploid status were strong independent predictors of progression. The 5-year survival rate free of progression was 84%. Patients with clinical stage T1c cancers had a significant progression-free survival advantage compared to those with clinical stage T2b/c disease (p = 0.0005). Impalpable tumors should not be regarded as insignificant or innocuous on the basis of pathological analysis. Disease-free survival in the stage T1c group was similar to that in the clin...Continue Reading

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Citations

Jan 1, 1997·World Journal of Urology·G E HanksT E Schultheiss
Oct 24, 2008·Der Urologe. Ausg. A·B Helpap, L Egevad
Jun 1, 1996·Urology·A E KatzR Buttyan
Jul 4, 1998·International Journal of Radiation Oncology, Biology, Physics·E M HorwitzG E Hanks
Dec 28, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·X ShuK Hemminki
Aug 20, 1997·Journal of the National Cancer Institute·D WaltregnyV Castronovo
Jul 17, 1998·Journal of the National Cancer Institute·D WaltregnyV Castronovo
Sep 26, 2003·The American Journal of Surgical Pathology·Michael E ChenPatricia Troncoso
May 18, 2000·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·C D Ames, M Gray
Apr 1, 1997·Journal of Clinical Pathology·M R Feneley, M C Parkinson
Jan 4, 2012·Histopathology·Liang ChengDaniel M Berney
May 28, 2011·The British Journal of Dermatology·X ShuK Hemminki
Nov 19, 2004·European Urology·Patrick J BastianWilliam G Nelson
Jul 15, 2015·Prostate International·Yoshiyasu AmiyaJun Shimazaki
Mar 14, 1998·American Journal of Clinical Oncology·M N MohideenS Luka

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