Prostate-specific antigen failure despite pathologically organ-confined and margin-negative prostate cancer: the basis for an adjuvant therapy trial

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
A V D'AmicoA Wein

Abstract

A multivariable analysis to evaluate the potential clinical and pathologic factors that predict for early biochemical failure in patients with pathologically organ-confined and margin-negative disease was performed to define patients who may benefit from adjuvant therapy. Three hundred forty-one prostate cancer patients treated with a radical retropubic prostatectomy between January 1989 and June 1995 and found to have pathologically organ-confined and margin-negative disease comprised the study population. A logistic regression multivariable analysis to evaluate the predictive value of the preoperative prostate-specific antigen (PSA) level, pathologic (prostatectomy) Gleason score, and pathologic stage on PSA failure occurring during the first postoperative year was performed. Predictors of PSA failure during the first postoperative year in patients with pathologically organ-confined disease included pathologic Gleason score > or = 7 (P = .0007) and preoperative PSA level greater than 10 (P < .0001). Corresponding 3-year freedom-from-PSA-failure rates for these pathologic organ-confined patients with both, one, or neither of these factors were 60%, 75% to 84%, and 95%, respectively (P < .0001). Prostate cancer patients with pa...Continue Reading

Citations

Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A V D'AmicoC N Coleman
Mar 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A V D'AmicoJ P Richie
Nov 9, 2000·BJU International·W D DunsmuirR S Kirby
Aug 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anthony V D'Amico
Aug 7, 2003·Cancer Investigation·Ofer YossepowitchPeter T Scardino
Aug 30, 2008·Scandinavian Journal of Urology and Nephrology·Thorstein SaetherAnders Angelsen
Apr 11, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Takeshi HashimotoYoshio Ohno
Jun 1, 2000·Radiology·S GrippR Willers
Jan 5, 2002·American Journal of Clinical Pathology·R T Vollmer, P A Humphrey
Jan 13, 2005·The American Journal of Surgical Pathology·Robert E EmersonLiang Cheng
Jul 16, 2005·Scandinavian Journal of Urology and Nephrology. Supplementum·John R SrigleyRodolfo Montironi
Jul 4, 1998·International Journal of Radiation Oncology, Biology, Physics·M J ZelefskyZ Fuks
May 15, 2003·Scandinavian Journal of Urology and Nephrology·Bo LennernäsSten Nilsson

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