PMID: 8939403Dec 1, 1996Paper

Prostate-specific antigen in amniotic fluid of normal and abnormal pregnancies

Clinical Biochemistry
D N MelegosE P Diamandis

Abstract

To examine if prostate-specific antigen (PSA) is present in amniotic fluid or maternal serum during pregnancy and if its presence is associated with fetal abnormalities. Samples tested included amniotic fluids from 853 pregnant women for whom amniocentesis was performed; 312 nonpregnant women who donated blood; 259 pregnant women who donated blood at various gestational ages. Amniotic fluid or serum PSA was measured with an ultrasensitive time-resolved immunofluorometric procedure. 372 pregnancies were studied for the presence of genotypic or phenotypic fetal abnormalities. PSA was present in most amniotic fluids; the median PSA concentration increased from gestational week 11 to 22 and stabilized thereafter until delivery. The most prominent PSA concentration change occurred during gestational weeks 13-14. Pregnant women had significantly higher serum PSA concentrations than nonpregnant women; the pattern of serum PSA concentration change during pregnancy was similar to that of amniotic fluid; however, serum PSA concentrations were lower by a factor of 20-40. No association existed between amniotic fluid PSA and maternal age, gender of fetus, or length of abstinence of mother from sexual intercourse. After gestational week 15,...Continue Reading

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Citations

Apr 4, 2006·International Journal of Legal Medicine·Itaru SatoTeruaki Iwamoto
Jun 1, 1996·Clinical Biochemistry·D N Melegos, E P Diamandis
Jul 5, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G BavieraC Carbone
Apr 7, 2000·Breast Cancer Research and Treatment·M H Black, E P Diamandis
Nov 6, 1998·Clinical Chemistry and Laboratory Medicine : CCLM·R Daher, M Beaini
Jan 9, 2015·Annals of African Medicine·Alireza Abdollahi
Jul 24, 2008·American Journal of Reproductive Immunology : AJRI·Jennifer Flatow CulhaneSabina Cauci
May 1, 1997·The Urologic Clinics of North America·E P Diamandis, H Yu
Apr 18, 2015·Indian Journal of Clinical Biochemistry : IJCB·Prakruti Dash
Mar 17, 2007·Critical Reviews in Clinical Laboratory Sciences·Angeliki SarandakouDemetrios Rizos
Jan 14, 2000·The Journal of Clinical Endocrinology and Metabolism·M MalatestaG Gazzanelli

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