PMID: 7545417Sep 1, 1995Paper

Prostate-specific antigen in serum of women with breast cancer

British Journal of Cancer
M GiaiE P Diamandis

Abstract

Prostate-specific antigen (PSA) was recently found in 30% of female breast tumours. In this study we have examined if PSA circulates in the blood of breast cancer patients and if serum PSA has any clinical application. We have compared serum PSA levels between women with and without breast cancer, between women with PSA-positive and PSA-negative breast cancer and between women with breast cancer before and after surgical removal of the tumour. We found that for women > or = 50 years, there is no difference in serum PSA between normal or breast cancer patients. We also could not find any difference in presurgical or post-surgical serum PSA between women who have PSA-positive or PSA-negative breast cancer. We found no correlation between PSA concentrations in matched presurgical and post-surgical sera, between presurgical sera and tumour cytosols and between post-surgical sera and tumour cytosols. High-performance liquid chromatography has shown that PSA in normal male serum consists mostly of PSA bound to alpha 1-antichymotrypsin (molecular weight approximately 100,000), and PSA in breast tumours and presurgical and post-surgical serum consists mostly of free PSA (molecular weight approximately 33,000). These data suggest that f...Continue Reading

Citations

Mar 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Y ZhaoF P Li
Apr 11, 2007·Prostate Cancer and Prostatic Diseases·E Elkord
Nov 15, 1996·International Journal of Cancer. Journal International Du Cancer·X FilellaA M Ballesta
Mar 5, 1999·Breast Cancer Research and Treatment·V StearnsD F Hayes
Apr 7, 2000·Breast Cancer Research and Treatment·M H Black, E P Diamandis
Dec 19, 2003·Breast Cancer Research : BCR·Noman KidwaiSunil Badve
Jul 20, 2007·Journal of Separation Science·Md Imtaiyaz HassanSavita Yadav
Jun 5, 2016·Clinical Chemistry·Natasha Musrap, Eleftherios P Diamandis
Mar 1, 1997·British Journal of Urology·E P Diamandis
Apr 18, 2015·Indian Journal of Clinical Biochemistry : IJCB·Prakruti Dash
Nov 26, 1999·Breast Cancer Research and Treatment·K A AlanenT J Nevalainen
Apr 1, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Eleftherios P DiamandisRicardo Azziz
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Jan 26, 2021·Advances in Radiation Oncology·Nicola J NasserAbed Agbarya
Jun 1, 1996·Clinical Biochemistry·D N Melegos, E P Diamandis

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