PMID: 9422553Jan 9, 1998Paper

Prostate-specific antigen levels are higher in African-American than in white patients in a multicenter registration study: results of RTOG 94-12

International Journal of Radiation Oncology, Biology, Physics
S VijayakumarM Bondy

Abstract

To compare serum prostate-specific antigen (PSA) levels in a national sample of African-American and white men with prostate cancer, and to attempt to explain any differences by using self-reported individual-level socioeconomic status adjustments. During 4 1/2 months in 1994-95, 709 patients with nonmetastatic prostate cancer were enrolled in this prospective study; 17.5% were African-American and 82.5% were white. Information about clinical stage, tumor grade, pretreatment PSA, type of insurance, and educational and income status was obtained. Serum PSA levels were measured and racial differences were found; how the differences were influenced by other patient- or tumor-related factors and if the differences could be explained by socioeconomic status disparities were determined. In univariate analyses, factors associated with the mean PSA levels were studied; log-converted values were used to yield a normal distribution. Multivariate analyses were done on log-linear models for description of association patterns among various categorical variables; a perfectly fitted model should have a correlation value (CV) of 1.0. The mean PSA level was higher in African-Americans (14.68 ng/ml) than in whites (9.82 ng/ml) (p = 0.001). Clin...Continue Reading

References

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Citations

Jun 27, 2002·Current Urology Reports·J W Moul
Oct 13, 2001·Urology·E P GelmannUNKNOWN PLCO Screening Trial Investigators
Nov 7, 1998·International Journal of Radiation Oncology, Biology, Physics·G K ZagarsC A Pettaway
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May 12, 2016·BMC Urology·Divya ShenoySrinivasan Vijayakumar
Jun 18, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chaundre K CrossAnthony V D'Amico
May 5, 2012·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Aguinaldo Cesar NardiArchimedes Nardozza
Jan 17, 2007·Prostate Cancer and Prostatic Diseases·K T BogenE A Holly
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Aug 11, 2021·American Journal of Human Biology : the Official Journal of the Human Biology Council·Alicia M DeLouizeJ Josh Snodgrass

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