PMID: 7538599Jun 1, 1995Paper

Prostate specific antigen regression and progression after androgen deprivation for localized and metastatic prostate cancer

The Journal of Urology
J E FowlerN T Braswell

Abstract

To identify prostate specific antigen (PSA) functions of prognostic significance in regard to treatment with androgen deprivation for prostate cancer we analyzed the pretreatment PSA, PSA half-life, PSA nadirs, times to PSA elevation and PSA doubling times in 245 patients with localized and 78 with metastatic disease who were treated with this modality. There was a direct correlation between the pretreatment PSA and the time to PSA elevation in patients with localized cancer (p = 0.000003) but no significant correlation in those with metastatic cancer. The PSA half-life was highly variable and did not correlate with other PSA functions of prognostic significance. Incremental increases in the PSA nadir correlated with the time to PSA elevation in patients with localized and metastatic cancer (p < 0.000001 and p = 0.00009, respectively), and with other parameters of prognostic significance. The median PSA doubling time in 26 patients with localized cancer in whom distant metastases did not develop (7.5 months) was significantly longer than that in 7 in whom new metastases developed (2.5 months) and in 43 with preexisting metastatic cancer (2.5 months) (p < 0.05 and p < 0.0001, respectively). In the 7 patients with localized cance...Continue Reading

Citations

Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Alan PollackEric M Horwitz
Apr 29, 2005·Radiology·Daniel T SchmidThomas F Hany
Aug 27, 2002·Current Treatment Options in Oncology·Brian I Rini, Eric J Small
Jun 27, 2015·Asian Journal of Andrology·Judd W Moul
Mar 16, 2001·Expert Opinion on Pharmacotherapy·D K Ornstein, R S Pruthi
Aug 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maha HussainUNKNOWN Southwest Oncology Group Trial 9346 (INT-0162)
May 24, 2013·International Journal of Molecular Sciences·Sakthivel MuniyanMing-Fong Lin
Dec 24, 2002·The Prostate·Brad GuessMark Scholz
Jun 17, 1998·The Journal of Urology·G F GreeneA C Von Eschenbach

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