Prostate-specific antigen testing and prostate biopsy: are self-reported lower urinary tract symptoms and health-related quality of life associated with the decision to undergo these investigations?

BJU International
Kerry AveryJenny Donovan

Abstract

To investigate whether men's self-reported health-related quality of life and lower urinary tract symptoms (LUTS) are associated with acceptance of prostate-specific antigen (PSA) testing and subsequent prostate biopsy. In a prospective questionnaire study of men aged 50-69 years, nested within the primary-care-based Prostate testing for cancer and Treatment study in nine UK areas, the Hospital Anxiety and Depression Scale (HADS), 12-item Short Form Health Survey (SF-12) and a self-reported LUTS measure (ICSmaleSF) were completed immediately before having a PSA test or prostate biopsy, or after not responding to an invitation for a PSA test or refusing a biopsy. Analyses compared 348 men accepting or 232 not responding to invitations for PSA testing and 318 accepting or 48 refusing a prostate biopsy. Men accepting or not responding to the invitation for a PSA test had similar HADS, SF-12 and LUTS scores. Men accepting a biopsy had similar HADS and SF-12 scores to those refusing biopsy, but significantly more LUTS (P < 0.01 for hesitancy, reduced stream, intermittency, incomplete emptying, frequency during the day). Depressed or anxious mood, comorbidity and LUTS were not associated with the decision to respond to invitations fo...Continue Reading

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Citations

Jan 17, 2012·European Urology·Kerry N L AveryJane M Blazeby
Nov 5, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J A LaneJ L Donovan
Apr 21, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Rhiannon C MacefieldJenny L Donovan
Mar 26, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Masaya ItoKazunori Kihara
Apr 8, 2010·British Journal of Cancer·R C MacefieldUNKNOWN ProtecT Study Group
Jul 11, 2018·PloS One·Marie KoitsaluYvonne Brandberg
Jul 22, 2014·Korean journal of urology·Ji Won HwangJin Seon Cho
Jun 23, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Karen ChiamDavid P Smith

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