Prostate specific antigen velocity does not aid prostate cancer detection in men with prior negative biopsy.

The Journal of Urology
Andrew J VickersHans Lilja

Abstract

Prostate specific antigen velocity has been proposed as a marker to aid in prostate cancer detection. We determined whether prostate specific antigen velocity could predict repeat biopsy results in men with persistently increased prostate specific antigen after initial negative biopsy. We identified 1,837 men who participated in the Göteborg or Rotterdam section of the European Randomized Screening study of Prostate Cancer and who underwent 1 or more subsequent prostate biopsies after an initial negative finding. We evaluated whether prostate specific antigen velocity improved predictive accuracy beyond that of prostate specific antigen alone. Of the 2,579 repeat biopsies 363 (14%) were positive for prostate cancer, of which 44 (1.7%) were high grade (Gleason score 7 or greater). Prostate specific antigen velocity was statistically associated with cancer risk but had low predictive accuracy (AUC 0.55, p <0.001). There was some evidence that prostate specific antigen velocity improved AUC compared to prostate specific antigen for high grade cancer. However, the small increase in risk associated with high prostate specific antigen velocity (from 1.7% to 2.8% as velocity increased from 0 to 1 ng/ml per year) had questionable clini...Continue Reading

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Citations

Nov 15, 2012·Annals of Family Medicine·Richard M HoffmanHarold C Sox
Jun 20, 2012·British Journal of Medical & Surgical Urology·Andrew J Vickers, Simon F Brewster
Jun 23, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Osama M Zaytoun, J Stephen Jones
Feb 24, 2012·BJU International·Michael MarbergerAndrew Vickers
Jul 15, 2015·Nature Reviews. Urology·Michael L BluteDavid F Jarrard
Aug 22, 2013·Journal of the National Cancer Institute. Monographs·Ruth EtzioniIris Lansdorp-Vogelaar
Jun 18, 2016·Current Opinion in Urology·Marlon PereraNathan Lawrentschuk
Dec 30, 2016·Future Science OA·Pranav SharmaJulio M Pow-Sang

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