Prostate-Specific Membrane Antigen Is a Potential Antiangiogenic Target in Adrenocortical Carcinoma

The Journal of Clinical Endocrinology and Metabolism
Michael J P CrowleyThomas J Fahey

Abstract

Adrenocortical carcinoma (ACC) is a rare tumor type with a poor prognosis and few therapeutic options. Assess prostate-specific membrane antigen (PSMA) expression as a potential novel therapeutic target for ACC. Expression of PSMA was evaluated in benign and malignant adrenal tumors and 1 patient with metastatic ACC. This study took place at a tertiary referral center. Fifty adrenal samples were evaluated, including 16 normal adrenal glands, 16 adrenocortical adenomas, 15 primary ACC, and 3 ACC metastases. Demographics, PSMA expression levels via real-time quantitative polymerase chain reaction and immunohistochemistry and whole-body positron emission tomography-computed tomography standardized uptake values for 1 patient. qPCR demonstrated an elevated level of PSMA in ACC relative to all benign tissues (P < .05). Immunohistochemistry localized PSMA expression to the neovasculature of ACC and confirmed overexpression of PSMA in ACC relative to benign tissues both in intensity and percentage of vessels stained (78% of ACC, 0% of normal adrenal, and 3.27% of adenoma-associated neovasculature; P < .001). Those with more than 25% PSMA-positive vessels were 33 times more likely to be malignant than benign (odds ratio, P < .001). Who...Continue Reading

Citations

Jan 18, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Philipp BackhausKambiz Rahbar
Nov 30, 2016·AJR. American Journal of Roentgenology·Anna N PaschaliConstantinos D Anagnostopoulos
Dec 3, 2016·Current Opinion in Oncology·Markus LusterFrederik A Verburg
May 2, 2019·Frontiers in Endocrinology·Yulin GuYiming Mu
Sep 3, 2021·Chemical Biology & Drug Design·Pejman ShahrokhiFarzaneh Rezazadeh
Jun 12, 2021·Clinical Nuclear Medicine·Qian ZhaoChangjing Zuo

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