PMID: 6159488Nov 7, 1980Paper

Prostatic acid phosphatase by radioimmunoassay. Sensitivity compared with enzymatic assay

JAMA : the Journal of the American Medical Association
G R LindholmJ D Batjer

Abstract

Prostatic acid phosphatase values in 98 patients with prostatic carcinoma were measured by a commercial radioimmunoassay (RIA) and by enzymatic assay. Forty-three carcinomas were staged by rigorous pathological criteria. Patients (N = 129) with benign prostatic hyperplasia were the control group. At 94% specificity, sensitivities of the RIA vs the enzymatic assay for clinically staged patients were as follows: stage A, 22% vs 6%; B, 29% vs 10%; C, 52% vs 38%; and D, 87% vs 80%. However, none of the seven patients with pathological stage A and B disease had a positive test result, and we suggest that variability in staging criteria accounts for the discrepant sensitivity claims reported. Prostatic acid phosphatase RIA should not be used for screening but as an adjunct for staging known prostatic carcinoma.

Citations

Jan 1, 1983·Cancer Metastasis Reviews·D J Laurence, A M Neville
Jun 16, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·S N Davies, J C Griffiths
Mar 26, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·A Skinningsrud, K Nustad
Mar 27, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·T M LinS P Halbert
Jan 1, 1983·Critical Reviews in Clinical Laboratory Sciences·J C Griffiths
Jan 1, 1982·Annals of the New York Academy of Sciences·C S KillianT M Chu

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