Prostatic Acid Phosphatase (PAP) Predicts Prostate Cancer Progress in a Population-Based Study: The Renewal of PAP?

Disease Markers
Huan XuYinghao Sun

Abstract

To characterize the disease progression and median survival of patients with prostate cancer (PCa) according to the prostatic-specific acid phosphatase (PAP) analysis in a population-based study from the Surveillance, Epidemiology, and End Results (SEER) database. Prostate cancer patients with completed PAP results were identified using the SEER database of the National Cancer Institute. The Mann-Whitney Sum test was utilized to compare the statistical significance for measurement data and ranked data. Data were stratified by ages, races, TNM Classification of Malignant Tumors (TNM), pathological grades, number of tumors, PAP, and survival duration. Multivariable logistic analysis was performed to identify predictors of the presence of invasion and metastases. Cox regression was analyzed for the factors associated with all-cause mortality and prostate cancer-specific mortality. Moreover, survival curve was used to detect the survival months. The unknown data were excluded from these tests. In total, there are 5184 PAP+ patients and 3161 PAP- patients involved. The Mann-Whitney Sum test showed that slightly greater tumor size (P = 0.03), elevated lymphatic (P = 0.005) and distant (P < 0.001) metastasis rate, higher pathological ...Continue Reading

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Citations

Dec 12, 2020·Journal of Cellular Physiology·Giovana Rampazzo TeixeiraFrancisco Eduardo Martinez
Mar 7, 2021·International Journal of Molecular Sciences·Celina Terán-RamírezMarco A Ramos-Ibarra
Jun 15, 2021·Current Oncology Reports·Karie D Runcie, Matthew C Dallos
Dec 23, 2019·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Nami TakadaTsutomu Daa

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SEER

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