Prostatic Adenocarcinoma, Prostatic Intraepithelial Neoplasia, and Intraductal Carcinoma

Surgical Pathology Clinics
Ming Zhou, Cristina Magi-Galluzzi

Abstract

Prostate carcinoma (PCa) exhibits a wide range of architectural and cytological features. Gleason grading remains as one of the most powerful histological prognostic parameters. However, it has evolved considerably. High-grade prostatic intraepithelial neoplasia (high-grade PIN) is accepted as a precursor lesion to PCa. Its detection in prostate biopsy is also considered as a risk factor for detecting cancer in subsequent biopsies. Such risk, however, has significantly decreased in recent studies. Intraductal carcinoma of the prostate (IDC-P) represents the intraductal spread of invasive cancer and constitutes a poor histologic parameter. This article reviews the key histological features of PCa, high-grade PIN and IDC-P, as well as the Gleason grading system that was most recently updated in 2005.

References

Apr 1, 1992·The American Journal of Surgical Pathology·G S HallJ I Epstein
Sep 1, 1995·British Journal of Urology·S AboseifP R Carroll
Jul 1, 1995·The American Journal of Surgical Pathology·P B Gaudin, J I Epstein
Mar 1, 1993·Human Pathology·D G BostwickD S Schultz
Oct 23, 1997·The American Journal of Surgical Pathology·A O ReyesP A Humphrey
Apr 16, 1998·The American Journal of Surgical Pathology·J R OppenheimerJ I Epstein
Aug 6, 1999·The American Journal of Surgical Pathology·M B AminJ R Srigley
May 8, 2001·American Journal of Clinical Pathology·P Thorson, P A Humphrey
May 16, 2002·Seminars in Urologic Oncology·Eric Schwartz, Peter Albertsen
Feb 27, 2003·The American Journal of Surgical Pathology·Ming ZhouMark A Rubin
Jan 24, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David G Bostwick, Junqi Qian
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Aug 13, 2005·The American Journal of Surgical Pathology·Cory SchlesingerKenneth A Iczkowski
Aug 13, 2005·The American Journal of Surgical Pathology·Jonathan I EpsteinUNKNOWN ISUP Grading Committee
Sep 19, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Charles C Guo, Jonathan I Epstein
Jul 10, 2007·Archives of Pathology & Laboratory Medicine·Ronald J CohenMark A Rubin
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun

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Citations

Nov 2, 2021·Technology in Cancer Research & Treatment·Kai ZhuQian Xu

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