Prostatic cancer therapy: comparison of external-beam radiation and I-125 seed implantation treatment of stages B and C neoplasms

Radiology
J D MortonR E Peschel

Abstract

Of 179 patients with stage B or C adenocarcinoma of the prostate, 106 underwent iodine-125 seed-implant therapy (I-125 SI) and 73 received external-beam radiation therapy (EB). A retrospective analysis determined disease-free survival rate, local tumor control, and complication rate for each treatment group. The 5-year disease-free survival rates for SI-treated patients were 75% for stage B and 30% for stage C groups. Corresponding rates for EB-treated patients were 75% and 40%, respectively. The rate of local tumor control for stage B patients was 85% for SI-treated and 88% for EB-treated patients. The corresponding rates for stage C tumors were 75% for SI-treated and 92% for EB-treated patients. The rate of long-term complications in each group was approximately 10%. For stage B cancer of the prostate, I-125 SI treatment is an acceptable alternative to EB therapy; our data are inconclusive regarding stage C treatment, but EB therapy is preferred.

Citations

Apr 1, 1986·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·D S Kapp
Dec 1, 1988·International Journal of Radiation Oncology, Biology, Physics·F LeeF J Pauli
Nov 1, 1996·The Urologic Clinics of North America·J C BlaskoP D Grimm
Jun 15, 1989·Cancer·R H SagermanP S Dalal
Jul 8, 2011·The Cochrane Database of Systematic Reviews·Frank PeinemannStefan Sauerland
Jan 1, 1996·Acta Oncologica·J E Frödin

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