Prostatic carcinogenesis evoked by cellular interaction

Environmental Health Perspectives
L W ChungA C von Eschenbach

Abstract

Inoculation of tumorigenic prostatic stroma and nontumorigenic prostatic epithelia into the subcutaneous space of syngeneic rats induced the development of carcinosarcoma. The induced tumors, which were composed of a mixture of adenocarcinoma and fibrosarcoma, were androgen responsive. This model offers a novel mechanism for prostatic carcinogenesis in which prostatic fibroblasts determine epithelial growth, androgen responsiveness, and tumorigenicity. Our results emphasize the potential importance of an epigenetic pathway in prostatic carcinogenesis.

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Citations

Apr 1, 1997·British Journal of Urology·S W HaywardG R Cunha
Jan 9, 2004·Reproductive Biology and Endocrinology : RB&E·Delisha A StewartRobert A Sikes
Jan 18, 2006·Cancer Letters·Isaac P Witz, Orlev Levy-Nissenbaum
Dec 25, 2009·Human Gene Therapy·Norman MaitlandUNKNOWN GIANT FP6 Consortium
Jul 12, 2014·BioMed Research International·Mariano Bizzarri, Alessandra Cucina

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