PMID: 8604808Apr 1, 1996Paper

Prostatic carcinoma with abundant xanthomatous cytoplasm. Foamy gland carcinoma

The American Journal of Surgical Pathology
R S Nelson, J I Epstein

Abstract

Foamy gland carcinoma, an unusual variant of prostate carcinoma, is characterized by abundant xanthomatous cytoplasm. We studied 38 needle biopsies in which at least one core contained cancer with >20% foamy morphology. On average, each cancer was 72% foamy, and 11 cancers were entirely foamy. In addition to the characteristic cytoplasm, 20 cases had abundant intraluminal dense pink amorphous secretions. Nuclear enlargement and prominent nucleoli were either absent of rare in 23 (61%) and 27 (71%) of foamy gland carcinomas, respectively. High-molecular-weight cyto-keratin stains were done in 20 cases; 19 foamy gland carcinomas were negative, confirming the diagnosis of carcinoma and one case had keratin staining inconsistent with a known benign pattern. Of the 27 cases with associated ordinary gland carcinoma on needle biopsy, 26 (96%) were Gleason sum greater than 4. Subsequent radical prostatectomy (RP) and transurethral resection demonstrating cancer were available in 17 cases. Of the 15 subsequent RPs, only five were organ-confined and only one was Gleason sum less than 5. The cancers in the RP group ranged from 1 to 90% foamy (mean, 39%). Foamy gland carcinoma must be recognized as carcinoma by its abundant foamy cytoplasm...Continue Reading

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Citations

Apr 12, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Omar Hameed, Peter A Humphrey
Oct 18, 2002·Histopathology·A CavazzaT V Colby
May 1, 1997·The American Journal of Surgical Pathology·S SchindlerH Yokoo
Oct 20, 1998·The American Journal of Surgical Pathology·P A HumphreyR T Vollmer
Apr 11, 2000·The American Journal of Surgical Pathology·V AdsayV Vaitkevicius
Aug 10, 2000·The American Journal of Surgical Pathology·A W Levi, J I Epstein
Aug 13, 2005·The American Journal of Surgical Pathology·Jonathan I EpsteinUNKNOWN ISUP Grading Committee
Aug 2, 2007·The American Journal of Surgical Pathology·Ai-Ying Chuang, Jonathan I Epstein
Nov 27, 2008·The American Journal of Surgical Pathology·Jin Zhao, Jonathan I Epstein
Nov 26, 2009·The American Journal of Surgical Pathology·Tineke WoltersGeert J L H van Leenders
Mar 11, 2010·The American Journal of Surgical Pathology·Oksana YaskivPeter A Humphrey
Jan 11, 2007·Journal of Clinical Pathology·P A Humphrey
Sep 27, 2013·Diagnostic Pathology·Simona StolnicuFrancisco F Nogales
Dec 17, 2009·The Journal of Urology·Jonathan I Epstein
Jun 27, 2015·International Journal of Experimental Pathology·Huilian HouXu Li
Jun 24, 2015·Annals of Diagnostic Pathology·Julián Arista-NasrJorge Albores-Saavedra
Mar 27, 2007·The Journal of Pathology·J-M MosqueraM A Rubin
Jan 24, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jonathan I Epstein
Aug 19, 2009·American Journal of Clinical Pathology·Pranil ChandraSherif Ibrahim
Jan 4, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jonathan I Epstein
Jan 4, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kiril Trpkov
Jan 4, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cristina Magi-Galluzzi
Jan 4, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Peter A Humphrey
Jan 4, 2012·Histopathology·Peter A Humphrey
Dec 29, 2015·The Prostate·Oleksandr N Kryvenko, Jonathan I Epstein
May 1, 1997·The American Journal of Surgical Pathology·S J CinaJ I Epstein
Apr 25, 2000·Human Gene Therapy·R SarkarH H Kazazian
Nov 16, 2019·Archives of Pathology & Laboratory Medicine·Chen Yang, Peter A Humphrey
Mar 30, 2016·International Journal of Surgical Pathology·Julian Arista-NasrBraulio Martinez-Benitez
Apr 9, 2017·Cold Spring Harbor Perspectives in Medicine·Peter A Humphrey
Oct 14, 2011·The Journal of Dermatology·Youichi OgawaShinji Shimada
Mar 4, 2006·Seminars in Diagnostic Pathology·Omar Hameed, Peter A Humphrey
Sep 9, 2008·Annals of Diagnostic Pathology·Julian Arista-NasrJorge Albores-Saavedra
Dec 1, 2008·Surgical Pathology Clinics·George J Netto, Jonathan I Epstein
Dec 1, 2008·Surgical Pathology Clinics·Samson W Fine

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