Prostatic ductal adenocarcinoma showing Bcl-2 expression

International Journal of Urology : Official Journal of the Japanese Urological Association
Ozden TulunayYusuf Z Müftüoglu

Abstract

Prostatic ductal adenocarcinoma represents a rare histological variant of prostatic carcinoma with features of a papillary lesion at cystoscopy. There are conflicts regarding the existence, origin, staging, grading, treatment and clinical behavior of this tumor. The aim of the present study is to examine the expression of Bcl-2 and p53 in prostatic ductal adenocarcinoma and to evaluate its origin by analyzing prostate specific antigen, prostate specific acid phosphatase, cytokeratins, epithelial membrane antigen and carcinoembryonic antigen expressions. The results confirmed the expression of prostate specific antigen and prostate specific acid phosphatase in prostatic ductal adenocarcinoma. The demonstrated expression of Bcl-2 was predominant in the better-differentiated tumor. Bcl-2 expression appears not to be associated with neuroendocrine differentiation as assessed by chromogranin A reactivity. Thus, the first case of a prostatic ductal adenocarcinoma showing Bcl-2 expression is presented. The tumor was negative for p53.

References

Oct 1, 1967·Cancer·M M Melicow, M R Pachter
Dec 1, 1970·The Journal of Urology·L F Belter, A I Dodson
Mar 1, 1996·International Journal of Urology : Official Journal of the Japanese Urological Association·H MatsushimaK Kawabe
Feb 19, 1998·British Journal of Urology·J D OxleyA G MacIver
Jul 14, 1999·The American Journal of Surgical Pathology·B J Bock, D G Bostwick

❮ Previous
Next ❯

Citations

Jul 28, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Souzan SanatiPeter A Humphrey
May 16, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Miklós TarjánTibor Tot
Apr 24, 2012·Scandinavian Journal of Urology and Nephrology·Miklós TarjánLászló Tabár
Aug 10, 2017·Journal of Pathology and Translational Medicine·Se Un JeongYong Mee Cho
Mar 17, 2020·Archiv der Pharmazie·Junjie ZhuZhichao Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.