Prostatic foamy gland carcinoma with aggressive behavior: clinicopathologic, immunohistochemical, and ultrastructural analysis

The American Journal of Surgical Pathology
T T TranX J Yang

Abstract

Foamy gland carcinoma is a recently described histologic variant of prostatic adenocarcinoma characterized by abundant foamy cytoplasm and minimal cytologic atypia. The biologic behavior and biochemical nature of the foamy adenocarcinoma cells are unknown. Six cases of prostatic adenocarcinoma with marked foamy appearance were identified from radical prostatectomies. Clinicopathologic, histochemical, immunohistochemical, and ultrastructural analyses were conducted. The patients ranged in age from 50 to 73 years (mean age, 65 years) with preoperative serum prostate-specific antigen levels ranging from 2.7 to 37.5 ng/mL (mean, 15.2 ng/mL). All six cases were bilateral high-volume tumors. Five of six patients had high-grade tumors with extraprostatic extension. The foamy tumor cells were negative for mucin and lipid stains, but were positive for colloidal iron and Alcian blue stain. Ultrastructurally, the foamy cells displayed numerous intracytoplasmic vesicles and numerous polyribosomes. The authors conclude that the foamy appearance of these tumor cells is the result of the presence of numerous intracytoplasmic vesicles, and not the result of the presence of lipid or neutral mucin. This study illustrates that foamy gland carcino...Continue Reading

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Citations

May 7, 2002·Diagnostic Cytopathology·Karl T K Chen
Dec 6, 2005·Virchows Archiv : an International Journal of Pathology·Antonio Lopez-BeltranRodolfo Montironi
Apr 12, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Omar Hameed, Peter A Humphrey
Aug 13, 2005·The American Journal of Surgical Pathology·Jonathan I EpsteinUNKNOWN ISUP Grading Committee
Aug 2, 2007·The American Journal of Surgical Pathology·Ai-Ying Chuang, Jonathan I Epstein
Nov 27, 2008·The American Journal of Surgical Pathology·Jin Zhao, Jonathan I Epstein
Mar 11, 2010·The American Journal of Surgical Pathology·Oksana YaskivPeter A Humphrey
Sep 27, 2013·Diagnostic Pathology·Simona StolnicuFrancisco F Nogales
Mar 27, 2007·The Journal of Pathology·J-M MosqueraM A Rubin
Jan 24, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jonathan I Epstein
Jan 4, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kiril Trpkov
Jan 4, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Peter A Humphrey
Jan 4, 2012·Histopathology·Peter A Humphrey
Nov 16, 2019·Archives of Pathology & Laboratory Medicine·Chen Yang, Peter A Humphrey
Apr 9, 2017·Cold Spring Harbor Perspectives in Medicine·Peter A Humphrey
Mar 30, 2016·International Journal of Surgical Pathology·Julian Arista-NasrBraulio Martinez-Benitez
Nov 6, 2009·Archives of Pathology & Laboratory Medicine·Rajal B Shah
Mar 4, 2010·Archives of Pathology & Laboratory Medicine·Omar Hameed, Peter A Humphrey
Sep 9, 2008·Annals of Diagnostic Pathology·Julian Arista-NasrJorge Albores-Saavedra
Dec 1, 2008·Surgical Pathology Clinics·Samson W Fine

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