Prostatic intraepithelial neoplasia and other changes during promotion and progression

Pathology, Research and Practice
T G PretlowT P Pretlow

Abstract

Preneoplastic lesions, early neoplastic lesions and carcinomas in situ have been demonstrated to be of great value for many purposes in many organ systems. Their recognition can be useful in epidemiological studies and can facilitate the selection of patients for therapeutic interventions. They can be used as "surrogate endpoint biomarkers" in studies aimed at the chemoprevention of cancers. In the lung, colon and various other organs, such markers are well recognized to be associated with the development of cancer in man. In the livers and colons of experimental animals, there has been detailed characterization of "enzyme-altered foci" (EAF) as "putative preneoplastic markers." The words "surrogate" and "putative" are important; the biological potential of these lesions needs to be elucidated in much greater detail. The quantification of early lesions that are associated with and sometimes precursors of neoplasia is of particular value because they are much more numerous, in most organ systems, than the carcinomas that develop in the same organs. The most abundant of these lesions show minimal or no morphological alterations. For example, EAF and aberrant crypts are more numerous than polyps in the colons of patients and exper...Continue Reading

References

Dec 1, 1979·Cancer·M G BrattainM Marks
Nov 1, 1977·Cancer·M G BrattainT G Pretlow
Jan 1, 1992·Journal of Cellular Biochemistry. Supplement·T P PretlowT A Stellato
Sep 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J H Beckstead
Dec 15, 1993·Journal of the National Cancer Institute·T P PretlowE L Kaplan

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Citations

Oct 21, 2000·Journal of Clinical Pathology·R MontironiA Lopez-Beltran
May 30, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T P Pretlow, T G Pretlow
Jul 4, 2002·Annals of the New York Academy of Sciences·Rodolfo MontironiMarina Scarpelli
Dec 25, 2007·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·Michel SouliéArnauld Villers

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