PMID: 7544835Oct 1, 1995Paper

Prostatic intraepithelial neoplasia is a risk factor for adenocarcinoma: predictive accuracy in needle biopsies

The Journal of Urology
D DavidsonM Stilmant

Abstract

High grade prostatic intraepithelial neoplasia is considered the most likely precursor of prostatic adenocarcinoma. However, the natural history and predictive value of prostatic intraepithelial neoplasia for cancer are unknown. To examine the predictive value of high grade prostatic intraepithelial neoplasia, we conducted a retrospective clinic based comparative study of 100 patients with high grade prostatic intraepithelial neoplasia and 112 without prostatic intraepithelial neoplasia on needle biopsies matched for digital rectal examination findings, patient age and serum prostate specific antigen level. Only patients who had 1 or more followup biopsies were included. Adenocarcinoma was identified in 35% of subsequent biopsies from patients with prostatic intraepithelial neoplasia, compared with 13% of control biopsies. The likelihood of finding cancer increased as the interval from initial biopsy increased. High grade prostatic intraepithelial neoplasia, patient age and serum prostate specific antigen concentration were jointly highly significant predictors of cancer, with prostatic intraepithelial neoplasia providing the highest risk ratio of 14.93 (95% confidence intervals 5.6 to 39.8). No other candidate predictor was si...Continue Reading

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Citations

Aug 1, 1996·The Prostate·D G BostwickA Lopez-Beltran
Apr 16, 1998·The Prostate·M H WeinsteinJ I Epstein
Jun 27, 2002·Current Urology Reports·D G Bostwick
Jun 18, 2005·European Urology·S JoniauH Van Poppel
May 7, 2002·Urology·Kenneth A IczkowskiDavid G Bostwick
May 9, 2003·The Urologic Clinics of North America·David G BostwickCory Schlesinger
Mar 22, 2003·Lancet·Angelo M DeMarzoJonathan I Epstein
Jun 29, 2002·Cancer Detection and Prevention·Marijana LijovicAlbert G Frauman
Jul 15, 2003·Urologic Oncology·Maxwell V MengGary D Grossfeld
Mar 31, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Oleksandr N KryvenkoBenjamin A Rybicki
Feb 28, 2007·Prostate Cancer and Prostatic Diseases·R S SvatekE A Benaim
Jan 5, 2000·BJU International·J L BurtonJ B Anderson
May 21, 1997·Journal of the National Cancer Institute·J W AquilinaD G Bostwick
Aug 19, 1999·Journal of the National Cancer Institute·C TremblayJ Sirois
Oct 23, 1997·The American Journal of Surgical Pathology·A O ReyesP A Humphrey
Dec 31, 1997·The American Journal of Surgical Pathology·K A IczkowskiD G Bostwick
Nov 10, 1998·The American Journal of Surgical Pathology·J I Epstein
Jan 13, 2000·The American Journal of Surgical Pathology·D M BermanJ I Epstein
Aug 13, 2005·The American Journal of Surgical Pathology·Cory SchlesingerKenneth A Iczkowski
Sep 8, 2006·Ultrasound Quarterly·Hossein Sadeghi-NejadVikram Dogra
Oct 21, 2000·Journal of Clinical Pathology·R MontironiA Lopez-Beltran
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Juan-Miguel MosqueraMark A Rubin

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