Prostatic relaxation induced by agmatine is decreased in spontaneously hypertensive rats

BJU International
Liang-Ming LeeJuei-Tang Cheng

Abstract

What's known on the subject? and What does the study add? Neurotransmitters are known to control prostate contractility. Agmatine is one of them and induces relaxation through imidazoline receptors. The paper shows that the action of agmatine is reduced in hypertensive rats, and that this change is related to the decrease of ATP-sensitive potassium channels in the prostate. The findings can increase our understanding of the possible underlying mechanism for the development of clinical benign prostatic hyperplasia. To compare agmatine-induced prostatic relaxation in hypertensive and control rats. To investigate the responsible mechanism(s) and the role of the ATP-sensitive potassium channel. Prostate strips were isolated from male spontaneously hypertensive (SH) rats and normal Wistar-Kyoto (WKY) rats for measurement of isometric tension. The strips were precontracted with 1 µmol/L phenylephrine or 50 mmol/L KCl. Dose-dependent relaxation of the prostatic strips was studied by cumulative administration of agmatine, 1 to 100 µmol/L, into the organ bath. Effects of specific antagonists on agmatine-induced relaxation were studied. Western blotting analysis was used to measure the gene expression of the ATP-sensitive potassium chann...Continue Reading

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Citations

Dec 10, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Bo Ram ChoiJong Kwan Park
Jul 3, 2018·Cardiovascular & Hematological Disorders Drug Targets·Luis Cobos-Puc, Hilda Aguayo-Morales
May 6, 2021·International Journal of Molecular Sciences·Pablo MaturanaElena Uribe

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