Prostatic tissue in testicular teratoma. A clinicopathologic and immunohistochemical study

Annals of Diagnostic Pathology
Andres A Roma, Peter A Humphrey

Abstract

The presence of prostatic differentiation as part of teratoma is very unusual and has been reported less than 20 times in the literature; however, all but 1 case were described in ovarian teratomas. We reviewed 45 specimens of germ cell tumors with teratoma component in postpuberal male patients. Original hematoxylin and eosin review failed to identify glands morphologically consistent with prostatic differentiation. Immunohistochemical stains performed on 10 specimens from 10 patients with small glandular and/or tubular structures revealed 1 case with glands positive for prostatic-specific antigen, prostatic-specific acid phosphatase, and prostein/P501S, whereas high-molecular-weight cytokeratin and p63 highlighted only basal cells. The glands were irregular in size and shape and contained mostly cuboidal to columnar luminal-type cells with occasional basal-type cells. Re-review of all the specimens revealed a second block from the same testis as well as 1 retroperitoneal lymph node with metastatic teratoma in the same patient, also immunohistochemically confirmed. These glands were seen in a smooth muscle stromal background, adjacent to classic gastrointestinal and tracheobronchial teratoma components. Our findings show immun...Continue Reading

References

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Nov 16, 2010·Annals of Diagnostic Pathology·Andres A Roma, Peter A Humphrey

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Citations

Mar 8, 2014·Annals of Diagnostic Pathology·I KilicaslanE Cakir
Sep 10, 2015·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Jamie StanhiserAndres A Roma

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