Prosthetic metals impair murine immune response and cytokine release in vivo and in vitro

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
J Y WangD T Tsukayama

Abstract

This study was designed to investigate whether prosthetic metals adversely affect immune responses and the release of immunoregulatory cytokines in vivo and in vitro. Titanium and cobalt-chromium alloy were injected into the peritoneal cavity of female mice. At 5, 8, and 12 weeks after the injection, the levels of cobalt and chromium in the blood were significantly increased compared with the levels in control mice; the level of titanium was not significantly changed until 12 weeks. The release of interleukin-2 was significantly inhibited by cobalt-chromium particles after 3 weeks; titanium particles did not have the same effect until 8 and 12 weeks. The release of interleukin-4 was significantly inhibited by cobalt-chromium particles after 3 weeks but was not significantly inhibited by titanium particles until 12 weeks. The release of interferon-gamma was significantly inhibited by cobalt-chromium particles only at 12 weeks and was not inhibited by titanium particles. The proliferation of T cells was significantly inhibited by cobalt-chromium particles at 3 weeks and by titanium particles at 8 and 12 weeks, and the proliferation of B cells was significantly inhibited by cobalt-chromium particles after 3 weeks but was not inhib...Continue Reading

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Citations

Mar 10, 2012·Journal of Materials Science. Materials in Medicine·Uwe WalschusMichael Schlosser
Sep 5, 2002·FEMS Immunology and Medical Microbiology·Richa ShrivastavaU C Chaturvedi
Oct 5, 2002·Clinical Microbiology Reviews·Mark E Shirtliff, Jon T Mader
Nov 13, 2010·Folia Histochemica Et Cytobiologica·Monika Łukomska-SymańskaJerzy Sokołowski
Aug 3, 2011·Indian Journal of Occupational and Environmental Medicine·Alok Prasad Das, Shikha Singh
May 14, 2016·Journal of Surgical Case Reports·Aisha ShaheenBenjamin A Kohl
May 28, 2016·International Journal of Molecular Sciences·Jiangxue WangYubo Fan
Oct 12, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hsin-Yi Lin, Joel D Bumgardner
Mar 12, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Daniel T O'ConnorK-L Paul Sung
May 6, 2004·Journal of Biomedical Materials Research. Part a·Rong Sen YangShing Hwa Liu
Jun 22, 2006·Journal of Biomedical Materials Research. Part a·Angela AuCarmelita G Frondoza
Nov 20, 2008·Clinical Orthopaedics and Related Research·Katherine E BrickWilliam D Lew
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Apr 2, 2019·Journal of Health & Pollution·Laila N IslamAktar Hossain
Sep 4, 2004·International Journal of Immunopathology and Pharmacology·L Di GiampaoloP Boscolo

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