Prosthetic valve endocarditis: clinicopathological correlates in 122 surgical specimens from 116 patients (1985-2004)

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Jonathan H LeeLarry M Baddour

Abstract

Few studies have documented the clinicopathological features of prosthetic valve endocarditis independently of native valve endocarditis. Retrospective analysis of patients undergoing cardiac surgery for prosthetic valve endocarditis at our institution (1985-2004). Medical records and microscopic slides were reviewed from 116 patients for demographics, infecting organisms, comorbidities, and pathologic features. Patients were 12-86 years old (mean, 59 years). Among 122 valves, 64% were from men and 67% were purely regurgitant. Aortic prosthetic valve endocarditis frequently affected men (76%); mitral prosthetic valve endocarditis often affected women (62%). Embolization occurred in 35% and heart failure in 32%. Prevalent predisposing conditions were the prosthetic valve alone (43%) and diabetes mellitus (20%). Prosthetic valve endocarditis was aortic or mitral in 98% and was active in 70%. Annular abscess or paravalvular leak affected mechanical valves more frequently than bioprosthetic (89% vs. 65%; P=.001). Causative organisms (n=116) included Staphylococcus aureus (30%), coagulase-negative staphylococcus (22%), viridans streptococci (18%), enterococci (10%), other streptococci (8%), and other organisms (12%). S. aureus was t...Continue Reading

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Citations

Jan 23, 2013·Internal and Emergency Medicine·Donato SantovitoFrancesco Cipollone
Sep 17, 2011·Current Treatment Options in Cardiovascular Medicine·Andrew Wang
Jun 19, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeannette Guarner
Mar 6, 2012·The Kaohsiung Journal of Medical Sciences·Ya-Ting ChangWen-Neng Chang
Apr 2, 2013·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Din LamBenjamin Archer
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Dec 24, 2014·Journal of Cardiothoracic and Vascular Anesthesia·Derek J De VryPaul S Pagel
Jul 10, 2012·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Mathieu C CastonguayJoseph J Maleszewski
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Jan 27, 2018·Journal of Fungi·Ryan KeanGordon Ramage
Jun 30, 2018·Surgical Infections·Rafael Quaresma GarridoCristiane C Lamas
Apr 14, 2015·Expert Review of Cardiovascular Therapy·Cormac T O'Connor, Thomas J Kiernan
Jun 3, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Nicola LucianiMario Tumbarello
Feb 13, 2018·The Korean Journal of Thoracic and Cardiovascular Surgery·Young Woong KimJoon Bum Kim
Nov 16, 2019·Journal of Cardiovascular Echography·Alberto CrestiUgo Limbruno
Sep 21, 2020·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Susanna T E CooperMary N Sheppard
Feb 3, 2021·Critical Reviews in Microbiology·Susana Patrícia LopesMaria Olívia Pereira
Feb 19, 2021·European Heart Journal. Case Reports·Nicholas SunderlandHunaid Vohra

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