PROTAC: A promising technology for cancer treatment.

European Journal of Medicinal Chemistry
Xin ZhouLi-Ping Sun

Abstract

Proteolysis-targeting chimeric molecules (PROTACs), which attract much more attention today, may be a potential way to treat cancer. PROTACs are made up of ligands of target proteins, E3 ligase recruiting elements and linkers. PROTACs can hijack the intracellular inherent ubiquitin proteasome system in cells to degrade different target proteins. PROTACs targeting different cancer-related proteins have been successfully developed and outperform small inhibitors, the traditional way of treating cancer. In this review, we focus on PROTACs targeting cancer-related proteins and their superiority over inhibitors.

Citations

Nov 16, 2020·European Journal of Medicinal Chemistry·Pedro Martín-Acosta, Xiangshu Xiao
Jan 17, 2021·European Journal of Medicinal Chemistry·Guoyi YanRui Li
Jul 20, 2021·Frontiers in Chemistry·Fei YuJihong Zhang
Aug 20, 2021·European Journal of Medicinal Chemistry·Chao WangDongming Xing
Sep 8, 2021·Journal of Hematology & Oncology·Haobin LiJiang-Jiang Qin

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