Protease-activated receptor 2 has pivotal roles in cellular mechanisms involved in experimental periodontitis.

Infection and Immunity
David M WongRobert N Pike

Abstract

The tissue destruction seen in chronic periodontitis is commonly accepted to involve extensive upregulation of the host inflammatory response. Protease-activated receptor 2 (PAR-2)-null mice infected with Porphyromonas gingivalis did not display periodontal bone resorption in contrast to wild-type-infected and PAR-1-null-infected mice. Histological examination of tissues confirmed the lowered bone resorption in PAR-2-null mice and identified a substantial decrease in mast cells infiltrating the periodontal tissues of these mice. T cells from P. gingivalis-infected or immunized PAR-2-null mice proliferated less in response to antigen than those from wild-type animals. CD90 (Thy1.2) expression on CD4(+) and CD8(+) T-cell-receptor beta (TCRbeta) T cells was significantly (P < 0.001) decreased in antigen-immunized PAR-2-null mice compared to sham-immunized PAR-2-null mice; this was not observed in wild-type controls. T cells from infected or antigen-immunized PAR-2-null mice had a significantly different Th1/inflammatory cytokine profile from wild-type cells: in particular, gamma interferon, interleukins (interleukin-2, -3, and -17), granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor alpha demonstrated lowe...Continue Reading

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Citations

Jul 25, 2014·Journal of Periodontology·Henrique Aparecido Bueno da SilvaMarinella Holzhausen
Feb 1, 2011·Pharmacology & Therapeutics·Mark N AdamsJohn D Hooper
Oct 16, 2015·Molecular Oral Microbiology·M J GuiE C Reynolds
Apr 21, 2010·Periodontology 2000·P Mark BartoldDavid R Haynes
Apr 17, 2014·Journal of Clinical Periodontology·Wan-Chien ChengLeonie S Taams
Jan 10, 2019·Journal of Clinical Periodontology·Reinhard Gruber
Sep 10, 2020·Frontiers in Immunology·Timo BuhlMartin Steinhoff
Jul 31, 2013·Journal of Medicinal Chemistry·Mei-Kwan YauDavid P Fairlie

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