Protease activity as a prognostic factor for wound healing in venous leg ulcers.

The Cochrane Database of Systematic Reviews
Maggie J WestbyRichard D Riley

Abstract

Venous leg ulcers (VLUs) are a common type of complex wound that have a negative impact on people's lives and incur high costs for health services and society. It has been suggested that prolonged high levels of protease activity in the later stages of the healing of chronic wounds may be associated with delayed healing. Protease modulating treatments have been developed which seek to modulate protease activity and thereby promote healing in chronic wounds. To determine whether protease activity is an independent prognostic factor for the healing of venous leg ulcers. In February 2018, we searched the following databases: Cochrane Central Register of Controlled Trials (CENTRAL), Ovid MEDLINE, Ovid Embase and CINAHL. We included prospective and retrospective longitudinal studies with any follow-up period that recruited people with VLUs and investigated whether protease activity in wound fluid was associated with future healing of VLUs. We included randomised controlled trials (RCTs) analysed as cohort studies, provided interventions were taken into account in the analysis, and case-control studies if there were no available cohort studies. We also included prediction model studies provided they reported separately associations o...Continue Reading

References

May 30, 1987·British Medical Journal·M J CallamC V Ruckley
Jun 1, 1988·The Journal of Investigative Dermatology·J Grøndahl-HansenK Danø
Jun 18, 1988·British Medical Journal·P D Coleridge SmithJ A Dormandy
Feb 28, 1995·Statistics in Medicine·C S BerkeyG A Colditz
Oct 1, 1994·The British Journal of Surgery·D A ShieldsP D Coleridge Smith
Nov 1, 1994·The British Journal of Dermatology·S H IbbotsonM J Goodfield
Feb 1, 1993·Experimental Dermatology·M PalolahtiA Vaheri
Feb 1, 1994·The British Journal of Surgery·O NelzénA Lindhagen
Jul 1, 1993·The Journal of Investigative Dermatology·A B WysockiF Grinnell
May 1, 1993·The British Journal of Surgery·M C StaceyB S Bhogal
Oct 1, 1995·International Journal of Dermatology·T Lotti, M Benci
Dec 1, 1995·Experimental Dermatology·I R HarrisE Ingham
May 1, 1996·The Journal of Investigative Dermatology·M WeckrothY T Konttinen
Jul 1, 1996·The British Journal of Dermatology·M VaalamoU K Saarialho-Kere
Jul 1, 1996·Archives of Dermatological Research·B H van BergenJ Schalkwijk
Nov 1, 1996·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·A B Wysocki
Dec 9, 1997·The British Journal of Dermatology·M WlaschekK Scharffetter-Kochanek
May 14, 1998·The Journal of Investigative Dermatology·F GrinnellW C Parks
Aug 15, 1998·Journal of the American Academy of Dermatology·D A Fisher
Aug 26, 1998·Archives of Dermatological Research·U K Saarialho-Kere
Oct 20, 1998·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·B C NwomehD R Yager
Dec 18, 1998·The Journal of Investigative Dermatology·R HoffmanJ Coad
Feb 3, 1999·The Journal of Surgical Research·B C NwomehD R Yager
May 7, 1999·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·C HeF Arnold
Jul 20, 1999·VASA. Zeitschrift für Gefässkrankheiten·A A RogersW Y Chen
Jul 27, 1999·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·A B WysockiT L Tuan
Aug 24, 1999·Archives of Dermatology·D J MargolisB L Strom
Nov 17, 1999·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·J F TarltonK D Harding
Jan 13, 2000·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·N J TrengoveG Schultz
Apr 25, 2000·Journal of Wound Care·R HoffmanM Eagle
Aug 23, 2000·Acta Dermato-venereologica·A Schmidtchen
Aug 26, 2000·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·M C Stacey, S D Mata
Nov 9, 2000·The British Journal of Dermatology·Y HerouyJ Norgauer
Nov 9, 2000·The Journal of Investigative Dermatology·O RechardtU Saarialho-Kere
Feb 24, 2001·Journal of the American Academy of Dermatology·I C ValenciaW H Eaglstein
Mar 10, 2001·Clinical Pharmacology and Therapeutics·UNKNOWN Biomarkers Definitions Working Group.
Jul 20, 2001·Annals of the New York Academy of Sciences·R A Clark
Jul 28, 2001·BMJ : British Medical Journal·D G Altman
Apr 30, 2002·Human Pathology·Ursula MirastschijskiUlpu Saarialho-Kere
Apr 30, 2002·International Journal of Cancer. Journal International Du Cancer·Pia Vihinen, Veli-Matti Kähäri
May 2, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Breda CullenLibby Morrison
May 2, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Glenn P LadwigGregory S Schultz

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Citations

May 23, 2020·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Maggie J WestbyJo C Dumville
Jun 26, 2020·Frontiers in Bioengineering and Biotechnology·Xi ZhangRui Li
Oct 30, 2020·F1000Research·Marta RoquéJavier Zamora
Jun 3, 2021·Journal of Personalized Medicine·Elena StallingsJavier Zamora
Aug 28, 2021·Medical Sciences : Open Access Journal·Marion BurckhardtAndreas Maier-Hasselmann

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