Protease binding by alpha 2 macroglobulin in cystic fibrosis

Clinica Chimica Acta; International Journal of Clinical Chemistry
M A BridgesA G Davidson

Abstract

The interaction of alpha 2 macroglobulin (alpha 2M) with exogenous proteases has been reported by others to be abnormal in cystic fibrosis (CF). We have re-examined these claims. Four parameters were considered:(1) the molar protease binding of alpha 2M; (2) the interaction of bovine cationic trypsin (BCT), complexed to alpha 2M, with low molecular mass substrate, benzoyl arginine ethyl ester (BAEE); (3) the stability of formed alpha 2 M-BCT complexes; and (4) the subunit structure of alpha 2M. We have found CF alpha 2M to be similar to control alpha 2M in every respect studied.

References

Sep 1, 1976·Pediatric Research·E ShapiraN L Nadler
Aug 9, 1976·Biochemical and Biophysical Research Communications·E ShapiraH L Nadler
Aug 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·E ShapiraH L Nadler
Aug 1, 1979·The Biochemical Journal·A J BarrettC A Sayers
Nov 15, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·Y Ben-YosephH L Nadler
Nov 5, 1974·Biochimica Et Biophysica Acta·M N Louvard, A Puigserver
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Mar 13, 1980·Biochemical and Biophysical Research Communications·E Shapira, R Menendez
Jan 5, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·M A BridgesL T Wong

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Citations

May 20, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·M A BridgesJ Johannson
Oct 27, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·B TümmlerJ R Riordan
Jan 1, 1983·Annals of the New York Academy of Sciences·E Shapira, H L Nadler
Jan 1, 1983·Annals of the New York Academy of Sciences·M A Bridges, D A Applegarth

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