Protease-dependent excitation of nodose ganglion neurons by commensal gut bacteria.

The Journal of Physiology
Alan E LomaxAlan E Lomax

Abstract

The vagus nerve has been implicated in mediating behavioural effects of the gut microbiota on the central nervous system. This study examined whether the secretory products of commensal gut bacteria can modulate the excitability of vagal afferent neurons with cell bodies in nodose ganglia. Cysteine proteases from commensal bacteria increased the excitability of vagal afferent neurons via activation of protease-activated receptor 2 and modulation of the voltage dependence of Na+ conductance activation. Lipopolysaccharide, a component of the cell wall of gram-negative bacteria, increased the excitability of nodose ganglia neurons via TLR4-dependent activation of nuclear factor kappa B. Our study identified potential mechanisms by which gut microbiota influences the activity of vagal afferent pathways, which may in turn impact on autonomic reflexes and behaviour. Behavioural studies have implicated vagal afferent neurons as an important component of the microbiota-gut-brain axis. However, the mechanisms underlying the ability of the gut microbiota to affect vagal afferent pathways are unclear. We examined the effect of supernatant from a community of 33 commensal gastrointestinal bacterial derived from a healthy human donor (micro...Continue Reading

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Citations

Mar 19, 2020·The Journal of Physiology·Arashdeep SinghGuillaume de Lartigue
Feb 12, 2021·Nature Communications·Frank A DucaTony K T Lam
Dec 31, 2020·Trends in Neurosciences·Bruno BonazHugo D Critchley
Jun 3, 2021·International Journal of Molecular Sciences·Marina Romaní-PérezYolanda Sanz

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