Protease inhibitor profiles in urticaria and angio-oedema

The British Journal of Dermatology
N EftekhariM W Greaves

Abstract

Plasma levels of six protease inhibitors have been measured in patients with chronic urticaria, chronic urticaria with angio-oedema, cold and cholinergic urticaria. In chronic urticaria C1 esterase inhibitor activity was increased compared with a reference control population but there was no detectable abnormality of any other protease inhibitor. Patients with chronic urticaria/angio-oedema showed a reduction in inter-alpha trypsin inhibitor. They also manifested a rise in C1 esterase inhibitor. In cold urticaria there was a significant lowering of alpha 1 antichymotrypsin. The reduction in alpha 1 antitrypsin in this group probably reflects a genetic difference compared with the control population. Patients with cholinergic urticaria also showed a reduction of alpha 1 antichymotrypsin. The elevated levels of alpha 2 macroglobulin in the three groups are probably due to differences in the mean age of these groups compared with the reference population. Comparison of levels of subgroups of patients with and without active lesions suggest that a consumptive effect may contribute to the reduced values, although it seems unlikely to account for them entirely. The results suggest that involvement of pharmacologically active products...Continue Reading

References

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Citations

Apr 27, 2000·Allergy·M W Greaves
Oct 3, 2003·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN European Respiratory Society
Sep 1, 1983·Clinical and Experimental Dermatology·S M BreathnachM W Greaves
Nov 1, 1981·The British Journal of Dermatology·C M LawrenceM W Greaves
May 1, 1982·Clinical and Experimental Dermatology·A K Black
Apr 1, 1985·The British Journal of Dermatology·H M DoeglasE Bleumink
Jun 1, 1985·Clinical Immunology and Immunopathology·S N BreitR Penny
Nov 25, 2000·Hospital Medicine·M Greaves
Apr 1, 1987·The British Journal of Dermatology·E WongA M Ward
May 1, 1988·The British Journal of Dermatology·A D OrmerodM W Greaves
Feb 1, 1991·The British Journal of Dermatology·P HumbertP Agache
Aug 1, 1989·The British Journal of Dermatology·J Berth-Jones, R A Graham-Brown
Sep 6, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A AsadyS Altrichter
Nov 30, 2020·Allergy·Natalya MaltsevaUNKNOWN COLD-CE Steering Committee
May 4, 2004·Immunology and Allergy Clinics of North America·John P Dice

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