Protease inhibitor resistance update: where are we now?

AIDS Patient Care and STDs
Rose Kim, John D Baxter

Abstract

The introduction of protease inhibitors (PIs) and highly active antiretroviral therapy in the mid-1990s dramatically altered the treatment of HIV infection, enabling suppression of viral replication to undetectable levels and preventing disease progression. Most PIs present a strong barrier against viral resistance; the accumulation of multiple mutations is often required to produce resistance. However, there is variability of resistance within the PI class, as demonstrated by the fact that some PIs require fewer mutations to confer resistance compared with others. Resistance to individual PIs as well as the development of broad cross-resistance to multiple agents in this class remain major challenges in clinical practice. Resistance to PIs may involve primary or secondary mutations in the protease gene in addition to mutations outside of protease in the gag cleavage and noncleavage sites. Primary mutations may be sufficient to confer resistance to select PIs. Secondary mutations may be required to produce resistance with some PIs, whereas other mutations may be compensatory, restoring activity of the viral protease or increasing the replicative capacity of the virus. Specific resistance patterns associated with individual PIs ...Continue Reading

References

Feb 19, 1998·AIDS·A C LeanderssonB Wahren
Oct 31, 1998·Antimicrobial Agents and Chemotherapy·D Boden, M Markowitz
May 18, 2000·JAMA : the Journal of the American Medical Association·M S HirschD D Richman
Mar 27, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·V Miller
Jul 4, 2001·Annals of Internal Medicine·E L MurphyUNKNOWN Viral Activation Transfusion Study Investigators
Aug 9, 2002·The New England Journal of Medicine·Susan J LittleDouglas D Richman
Jan 25, 2003·Antimicrobial Agents and Chemotherapy·Terri WatkinsRonald Swanstrom
May 15, 2004·AIDS Patient Care and STDs·Michael Kozal
Jun 10, 2004·AIDS Patient Care and STDs·Daniel R Kuritzkes
Jun 16, 2004·Antiviral Research·Barbara R TaggartMelinda Hollingshead
Aug 24, 2004·Current Drug Metabolism·Carmen de Mendoza, Vincent Soriano
Dec 9, 2004·Pharmacotherapy·Anthony J BustiDavid M Margolis
Jan 26, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Richard M NovakUNKNOWN Terry Beirn Community Programs for Clinical Research on AIDS 058 Study Team
Apr 28, 2005·Antimicrobial Agents and Chemotherapy·Valentina SvicherCarlo Federico Perno
May 21, 2005·AIDS·Elizabeth J PhillipsNeil H Shear
Jun 25, 2005·Journal of Medical Virology·Veronica SvedhemA Sönnerborg
Jul 21, 2005·Journal of Medical Virology·Berta RodesUNKNOWN Red de Investigación en SIDA
Aug 3, 2005·Drugs·Katherine F Croom, Susan J Keam
Aug 16, 2005·Lancet·Ginger LehrmanDavid M Margolis
Feb 8, 2006·Health & Social Care in the Community·Michele FosterCaroline Glendinning
Aug 15, 2006·JAMA : the Journal of the American Medical Association·Scott M HammerUNKNOWN International AIDS Society-USA panel

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Citations

Mar 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yan HuRaffi V Aroian
Dec 15, 2010·AIDS Research and Human Retroviruses·Fernando Flor-ParraPilar Pérez-Romero
Dec 17, 2011·BMC Bioinformatics·Kathleen M DohertyMala L Radhakrishnan
Apr 18, 2009·Current Opinion in HIV and AIDS·Kimberly A StrubleGuoxing Greg Soon
Oct 29, 2013·Journal of Medicinal Chemistry·Advait JoshiMats Larhed
Apr 16, 2014·British Journal of Clinical Pharmacology·Alice TsengElizabeth J Phillips
Feb 26, 2015·HIV Medicine·J D BaxterUNKNOWN International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) START Study Group
Jul 22, 2020·Expert Opinion on Drug Discovery·Fisayo A OlotuMahmoud E S Soliman
Jun 27, 2019·Current Topics in Medicinal Chemistry·Chandrashekhar Voshavar
May 12, 2020·ChemMedChem·André L C S NascimentoMarlus Chorilli

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