Protease inhibitors and carcinogenesis: a review

Cancer Investigation
G A Clawson

Abstract

This brief review article deals with the subject of anticarcinogenic activity of protease inhibitors (PI). Three basic premises are made: (1) Although PI are prevalent constituents of dietary staples such as soy products, which have been epidemiologically associated with reduced cancer incidences at multiple target sites, they are unlikely to be the active anticarcinogenic entities. Cooked soy products, which are devoid of PI activity, are equally as effective at reducing cancer development as raw soy products. Isoflavones are likely to represent major chemopreventive agents in soy, although other constituents may well contribute. (2) Although supplementation of diets with PI (natural or synthetic), or direct topical administration, results in lower cancer incidences in many experimental models in vivo, this effect appears to be indirect. Dietary PI are, in general, poorly absorbed from the GI tract, and never reach target organs in any measurable quantity. The most attractive hypothesis is that dietary PI could induce synthesis and distribution of endogenous PI (acute-phase reactants), which have widespread effects on cell growth and behavior. Effects of topical administration of PI also encompass prominent anti-inflammatory e...Continue Reading

References

Jan 1, 1979·Advances in Cancer Research·E H Cooper, J Stone
Jan 1, 1977·Hoppe-Seyler's Zeitschrift für physiologische Chemie·H SchiesslerH Fritz
Jun 13, 1979·Biochemical and Biophysical Research Communications·B D GoldsteinW Troll
Jan 1, 1977·Experimental Cell Research·R L BrownE Stubblefield
Feb 1, 1992·International Journal of Radiation Biology·A I Gaziev, M P Kutsyi
Nov 1, 1992·Cancer Metastasis Reviews·L R ZacharskiF A Calvo
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·P C Billings, J M Habres
Apr 17, 1991·Journal of the National Cancer Institute·M Messina, S Barnes
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P C BillingsJ M Habres
Jan 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A CiechanoverG M Brodeur
Jan 1, 1991·Free Radical Research Communications·W Troll
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D H PerlmutterR J Fallon
Jan 1, 1990·Free Radical Biology & Medicine·E Graf, J W Eaton
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A KumatoriA Ichihara
Aug 15, 1985·Cancer·E Graf, J W Eaton
Jan 1, 1987·Advances in Cancer Research·W TrollK Frenkel
Apr 14, 1987·Biochemical and Biophysical Research Communications·M TsudaT Katsunuma
Sep 1, 1987·The British Journal of Nutrition·J CalamC J Springer
Jan 1, 1987·The New England Journal of Medicine·W C WillettF E Speizer
Feb 1, 1985·International Journal of Peptide and Protein Research·Y Birk
Dec 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H P Schnebli, M M Burger
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J O'Donnell-Tormey, J P Quigley
May 1, 1984·Archives of Biochemistry and Biophysics·T M KuoC A Ryan

❮ Previous
Next ❯

Citations

Nov 15, 2002·Cancer Detection and Prevention·Inga ZelvyteSabina Janciauskiene
May 22, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·T García-GascaA Blanco-Labra
Jul 26, 2003·Protein Expression and Purification·Marcello DurantiPaolo Morazzoni
Dec 24, 2004·Critical Reviews in Food Science and Nutrition·Ki Won LeeChang Yong Lee
Apr 6, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·W BodeK Maskos
Aug 6, 2005·Protein Science : a Publication of the Protein Society·Ying-Xia ZhangYun Zhang
Apr 18, 2009·Molecular Aspects of Medicine·Tobias JungTilman Grune
Apr 3, 2003·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·I ZelvyteS Janciauskiene
Mar 10, 2000·Biochimica Et Biophysica Acta·W Bode, R Huber

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Mammalian Genome : Official Journal of the International Mammalian Genome Society
V MayauM Debatisse
Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
A KabaC Chany
© 2021 Meta ULC. All rights reserved