Proteases and protease inhibitors in tumor progression

Advances in Experimental Medicine and Biology
Y A DeClerckW E Laug

Abstract

Our understanding of the role of matrix degrading proteases in cancer has dramatically expanded over the last two decades. From correlative observations linking proteases to cancer progression, we have accumulated evidence supporting a causal role for proteases in various steps of tumor progression and have become increasingly aware of the complex interactions that exist among proteases. Specific natural inhibitors of these proteases have also been identified and their role as potent cytostatic agents in cancer has been suggested. In this article some of the concepts on the role of proteases in cancer are discussed and examples of cooperation between matrix metalloproteinases and the plasmin/plasminogen activators system are presented. The role of protease inhibitors such as tissue inhibitor of metalloproteinases-2 (TIMP-2) and plasminogen activator inhibitor-2 (PAI-2) as inhibitors of tumor growth, invasion and metastasis is discussed.

Citations

Nov 12, 1998·Journal of the National Cancer Institute·L M Wahl, H K Kleinman
Aug 24, 2000·International Journal of Cancer. Journal International Du Cancer·E FariasL Puricelli
Sep 20, 2000·The Journal of Biological Chemistry·S L RazaL A Cornelius
Feb 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andreas ScorilasEleftherios P Diamandis
Oct 23, 2004·Journal of Cellular Physiology·Xiaoling JiangSean P Scully
Oct 23, 2004·International Journal of Cancer. Journal International Du Cancer·Benoit PaquetteAndré M Cantin
Jun 18, 2005·Clinical Chemistry·Christina V ObiezuEleftherios P Diamandis
Jul 1, 2009·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Natalie E Goldberger, Kent W Hunter
Jan 30, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kyu-Sil ChoiDavid M Waisman
Apr 3, 2003·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·I ZelvyteS Janciauskiene
Apr 25, 2000·The Journal of Biological Chemistry·J MaiB F Sloane
Sep 2, 2000·The Journal of Biological Chemistry·T J HarveyJ A Clements
Jul 23, 1999·Annals of the New York Academy of Sciences·B L Lokeshwar
Nov 20, 2002·Annals of the New York Academy of Sciences·Rena M HillNigel P Birch
Aug 12, 2003·Breast Cancer Research and Treatment·M G PetersE Bal de Kier Joffé
Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Nadim JessaniBenjamin F Cravatt
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·S SperlL Moroder
Nov 5, 1999·The Journal of Clinical Investigation·G P ShiH A Chapman
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y LiuB F Cravatt
Jul 10, 2001·Surgical Endoscopy·M ProssH U Schulz
Jan 5, 2007·Journal of Medicinal Food·J K Kumi-DiakaVanessa Horman
May 17, 2008·Molecular Cancer Therapeutics·Shang-Chiung ChenMichael K K Wong
Aug 10, 2006·Chemical Reviews·Michael J Evans, Benjamin F Cravatt
Mar 10, 2000·Biochimica Et Biophysica Acta·J MaiB F Sloane
Mar 3, 2001·Neoplasia : an International Journal for Oncology Research·M SameniB F Sloane

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