Proteases and Their Inhibitors in Chronic Obstructive Pulmonary Disease.

Journal of Clinical Medicine
Tapan DeyC C Taggart

Abstract

In the context of respiratory disease, chronic obstructive pulmonary disease (COPD) is the leading cause of mortality worldwide. Despite much development in the area of drug development, currently there are no effective medicines available for the treatment of this disease. An imbalance in the protease: Antiprotease ratio in the COPD lung remains an important aspect of COPD pathophysiology and several studies have shown the efficacy of antiprotease therapy in both in vitro and in vivo COPD models. However more in-depth studies will be required to validate the efficacy of lead drug molecules targeting these proteases. This review discusses the current status of protease-directed drugs used for treating COPD and explores the future prospects of utilizing the potential of antiprotease-based therapeutics as a treatment for this disease.

References

Mar 1, 1990·The Journal of Clinical Investigation·C P SommerhoffG H Caughey
Oct 1, 1990·The Journal of Allergy and Clinical Immunology·L B Schwartz
Apr 1, 1970·The Biochemical Journal·A J Barrett
Mar 1, 1997·American Journal of Respiratory and Critical Care Medicine·T C O'ShaughnessyP K Jeffery
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·K C ElrodR D Tanaka
Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·M SaettaL M Fabbri
Apr 1, 1999·American Journal of Respiratory Cell and Molecular Biology·F BühlingT Welte
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·W Macnee, I Rahman
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E J CampbellC A Owen
Dec 6, 2000·The Journal of Clinical Investigation·Y KasaharaN F Voelkel
Dec 6, 2000·The Journal of Experimental Medicine·Z WangJ A Elias
Jun 9, 2001·The Journal of Allergy and Clinical Immunology·M T KrishnaS Holgate
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Se-Woong OhWilliam R Henderson
Mar 16, 2002·The Journal of Biological Chemistry·Ulrika KarlsonLars Hellman
Aug 21, 2002·American Journal of Respiratory and Critical Care Medicine·Takashige KurakiMinoru Yoshida
Oct 3, 2002·American Journal of Respiratory and Critical Care Medicine·Joanne L WrightAndrew Churg
Feb 28, 2003·European Journal of Biochemistry·Qi PengAndrew F Walls
Apr 23, 2003·American Journal of Respiratory Cell and Molecular Biology·Kazutetsu AoshibaAtsushi Nagai
Oct 30, 2003·The European Respiratory Journal·P J BarnesR A Pauwels
Feb 11, 2004·Chest·Naoko YokohoriUNKNOWN Respiratory Failure Research Group in Japan
Dec 24, 2004·The Journal of Biological Chemistry·Elena TchougounovaGunnar Pejler
Feb 1, 2005·The American Journal of Pathology·Nathalie BussoEric Grouzmann
Feb 3, 2005·The European Respiratory Journal·K ImaiJ M D'Armiento
Feb 22, 2005·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·S MoletV Lagente
Mar 2, 2005·The European Respiratory Journal·S HodgeP N Reynolds
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tao ZhengJack A Elias
Aug 23, 2005·Proceedings of the American Thoracic Society·Sanjay Sethi
Sep 30, 2005·International Archives of Allergy and Immunology·Ken BrackeRomain A Pauwels
Oct 18, 2005·Thorax·P T G Elkington, J S Friedland
Dec 13, 2005·Treatments in Respiratory Medicine·Dennis NowakRuediger Sandtmann

❮ Previous
Next ❯

Citations

Jun 4, 2019·Marine Drugs·Justine DemayBenjamin Marie
Feb 27, 2020·American Journal of Respiratory Cell and Molecular Biology·Kiyoshi UemasuAtsuyasu Sato
Apr 25, 2020·Cells·Valeria De PasqualeLuigi Michele Pavone
Feb 21, 2019·American Journal of Respiratory and Critical Care Medicine·Srikanth R Janga, Sarah F Hamm-Alvarez
Nov 18, 2020·BMC Pulmonary Medicine·Durga MahorKailash C Pandey
May 8, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Luciana P TavaresFrancesca Levi-Schaffer
Apr 15, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Eleonore Fröhlich, Sharareh Salar-Behzadi
Jul 3, 2021·International Journal of Molecular Sciences·Marta Martín-FernándezEduardo Tamayo

❮ Previous
Next ❯

Methods Mentioned

BETA
bronchoalveolar lavage
lavage
biopsies
genetic knockdown

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
M L DelforgeJ P Van Vooren
© 2022 Meta ULC. All rights reserved