Proteases from dengue, West Nile and Zika viruses as drug targets

Biophysics Reviews
Christoph Nitsche

Abstract

Proteases from flaviviruses have gained substantial interest as potential drug targets to combat infectious diseases caused by dengue, West Nile, Zika and related viruses. Despite nearly two decades of drug discovery campaigns, promising lead compounds for clinical trials have not yet been identified. The main challenges for successful lead compound development are associated with limited drug-likeness of inhibitors and structural ambiguity of the protease target. This brief review focuses on the available information on the structure of flavivirus proteases and their interactions with inhibitors and attempts to point the way forward for successful identification of future lead compounds.

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Citations

Nov 20, 2019·Biophysics Reviews·Damien Hall
Apr 9, 2020·International Journal of Molecular Sciences·Qingxin Li, CongBao Kang
Jun 4, 2020·Scientific Reports·Nikhil PathakJinn-Moon Yang
Sep 23, 2020·ChemMedChem·Tommaso FelicettiRolando Cannalire
Nov 17, 2020·Frontiers in Pharmacology·Xiangling CuiShan Cen
Jul 29, 2019·Bioorganic & Medicinal Chemistry·Edeildo Ferreira da Silva-Júnior, João Xavier de Araújo-Júnior
Feb 27, 2021·Bioorganic Chemistry·Caroline Sprengel LimaLuis Octavio Regasini
Apr 15, 2021·Journal of Medicinal Chemistry·Nikos KühlChristian D Klein
Jul 3, 2021·Life·Rong ZhaoJimin Cao
Jun 25, 2021·Chemical Science·Richard Morewood, Christoph Nitsche
Jul 29, 2021·Journal of Biomolecular Structure & Dynamics·Gopishankar ThirumoorthyVasantha Veerappa Lakshmaiah
Aug 31, 2021·RSC Medicinal Chemistry·Saan Voss, Christoph Nitsche

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Methods Mentioned

BETA
X-ray
NMR

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