Proteases Upregulation in Sporadic Alzheimer's Disease Brain

Journal of Alzheimer's Disease : JAD
Alessandro MedoroClaudio Russo

Abstract

Certain proteases are involved in Alzheimer's disease (AD) and their erroneous control may contribute to the pathology onset and progression. In this study we evaluated the cerebral expression of eight proteases, involved in both AβPP processing and extracellular matrix remodeling. Among these proteases, ADAM10, ADAMTS1, Cathepsin D, and Meprin β show a significantly higher mRNAs expression in sporadic AD subjects versus controls, while ADAMTS1, Cathepsin D, and Meprin β show an increment also at the protein level. These data indicate that transcriptional events affecting brain proteases are activated in AD patients, suggesting a link between proteolysis and AD.

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Citations

Oct 13, 2019·The Journal of Biological Chemistry·Preeti Kumaran MenonAnna-Lena Ström
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Nov 22, 2019·The Journal of Biological Chemistry·Preeti Kumaran MenonAnna-Lena Ström
Jul 16, 2019·Inorganic Chemistry·Ewelina Stefaniak, Wojciech Bal

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